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Bhak, Jong
KOrean GenomIcs Center(KOGIC)
Research Interests
  • Geromics, genomics, bioinformatics, protein Engineering, OMICS

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PPP1R1B-STARD3 chimeric fusion transcript in human gastric cancer promotes tumorigenesis through activation of PI3K/AKT signaling

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dc.contributor.author Yun, S. M. ko
dc.contributor.author Yoon, K. ko
dc.contributor.author Lee, S. ko
dc.contributor.author Kim, E. ko
dc.contributor.author Kong, S-H ko
dc.contributor.author Choe, J. ko
dc.contributor.author Kang, J. M. ko
dc.contributor.author Han, T-S ko
dc.contributor.author Kim, P. ko
dc.contributor.author Choi, Y. ko
dc.contributor.author Jho, S. ko
dc.contributor.author Yoo, H. ko
dc.contributor.author Bhak, J. ko
dc.contributor.author Yang, H-K ko
dc.contributor.author Kim, S-J ko
dc.date.available 2015-07-03T00:56:45Z -
dc.date.created 2015-07-03 ko
dc.date.issued 2014-11 -
dc.identifier.citation ONCOGENE, v.33, no.46, pp.5341 - 5347 ko
dc.identifier.issn 0950-9232 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/11842 -
dc.identifier.uri http://www.nature.com/onc/journal/v33/n46/full/onc2013472a.html ko
dc.description.abstract Fusion genes act as potent oncogenes, resulting from chromosomal rearrangements or abnormal transcription in many human cancers. Although multiple gastric cancer genomes have been sequenced, the driving recurrent gene fusions have not been well characterized. Here, we used paired-end transcriptome sequencing to identify novel gene fusions in 18 human gastric cancer cell lines and 18 pairs of primary human gastric cancer tissues and their adjacent normal tissues. Multiple samples revealed expression of PPP1R1B-STARD3 fusion transcript. The presence of PPP1R1B-STARD3 correlated with elevated levels of PPP1R1B mRNA. PPP1R1B-STARD3 fusion transcript was detected in 21.3% of primary human gastric cancers but not in adjacent matched normal gastric tissues. Based on reverse transcription PCR analysis of DNA, unlike other fusions described in gastric cancer, the PPP1R1B-STARD3 appears to be generated by RNA processing without chromosomal rearrangement. Overexpression of PPP1R1B-STARD3 in MKN-28 significantly increased cell proliferation and colony formation. This increased proliferation was mediated by activation of phosphatidylinositol-3-kinase (PI3K)/AKT signaling. Furthermore, expression of PPP1R1B-STARD3 fusion transcript enhanced the tumor growth of MKN-28 cells in athymic nude mice. These findings show that PPP1R1B-STARD3 fusion transcript has a key role in subsets of gastric cancers through the activation of PI3K/AKT signaling ko
dc.description.statementofresponsibility close -
dc.language ENG ko
dc.publisher NATURE PUBLISHING GROUP ko
dc.subject fusion transcript ko
dc.subject gastric cancer ko
dc.subject transcriptome sequencing ko
dc.title PPP1R1B-STARD3 chimeric fusion transcript in human gastric cancer promotes tumorigenesis through activation of PI3K/AKT signaling ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84887894780 ko
dc.identifier.wosid 000345120600004 ko
dc.type.rims ART ko
dc.description.wostc 2 *
dc.description.scopustc 1 *
dc.date.tcdate 2015-12-28 *
dc.date.scptcdate 2015-11-04 *
dc.identifier.doi 10.1038/onc.2013.472 ko
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