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Cho, Jaeweon
OWIELAB(Organic-Water Interface Engineering Laboratory)
Research Interests
  • Convergence of Science and Arts, Feces Standard Money (FSM), Water & Energy

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Oxidative stress responses of Daphnia magna exposed to TiO2 nanoparticles according to size fraction

Cited 66 times inthomson ciCited 63 times inthomson ci
Title
Oxidative stress responses of Daphnia magna exposed to TiO2 nanoparticles according to size fraction
Author
Kim, Ki TaeKlaine, Stephen J.Cho, JaeweonKim, Sang-HoonKim, Sang D.
Keywords
Antioxidant enzyme; Daphnia magna; Nanoparticles; Titanium dioxide; Toxicity
Issue Date
2010-04
Publisher
ELSEVIER SCIENCE BV
Citation
SCIENCE OF THE TOTAL ENVIRONMENT, v.408, no.10, pp.2268 - 2272
Abstract
Size is one of important factors determining titanium dioxide nanoparticle (TiO2 NP) toxicity since penetration is eased with decreasing particle size and bioavailability is increased The effect of particle size on oxidative stress against titanium dioxide nanoparticle (TiO2 NP) exposure to Daphnia magna was investigated with both acute and chronic toxicity tests Experiments on biochemical responses, repeatedly performed after size fractionation of the NPs using filtration, focused on the activities of four antioxidant enzymes. catalase (CAT), superoxide dismutase (SOD). glutathione peroxidase (GPX). and glutathione-S-transferase (GST) In the chronic bioassay, the mortality was significantly increased at TiO2 NP concentrations of 5 and 10 mg/L; however, no reduction of the reproduction ability was observed. Biochemical measurements showed that TiO2 NP exposure significantly increased the antioxidant enzyme activities in D magna CAT. GPX and GST. but not SOD, showed a concentration-dependent increase In terms of size fraction, particles ranging from 400 to 800 nm exhibited an increase of antioxidant enzyme activities in GST and GPX These biochemical level observations suggested that TiO2 NP toxicity was mediated by reactive oxygen species (ROS) generation via oxidative stress in D. magna. The Increased mortality at the concentration of 5 mg/L in the chronic bioassay was attributed to accumulated TiO2 NPs in the intestine of D magna, which might induce effects such as oxidative stress relating to the induction of antioxidant enzymes (C) 2010 Elsevier B.V. All rights reserved
URI
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DOI
10.1016/j.scitotenv.2010.01.041
ISSN
0048-9697
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