BROWSE

Related Researcher

Author's Photo

Cho, Hyungjoon
Biomedical Imaging Science and Engineering Lab(BISE)
Research Interests
  • Imaging tumor microenvironments, susceptibility contrast based MR structural imaging, ultra fast acquisitions of dynamic MR, algorithm/Hardware development for magnetic particle imaging

ITEM VIEW & DOWNLOAD

Simultaneous evaluation of vascular morphology, blood volume and transvascular permeability using SPION-based, dual-contrast MRI: Imaging optimization and feasibility test

DC Field Value Language
dc.contributor.author Kwon, Heon-Ju ko
dc.contributor.author Shim, Woo Hyun ko
dc.contributor.author Cho, Gyunggoo ko
dc.contributor.author Cho, Hyungjoon ko
dc.contributor.author Jung, Hoe Su ko
dc.contributor.author Lee, Chang Kyung ko
dc.contributor.author Lee, Yong Seok ko
dc.contributor.author Baek, Jin Hee ko
dc.contributor.author Kim, Eun Ju ko
dc.contributor.author Suh, Ji-Yeon ko
dc.contributor.author Sung, Yu Sub ko
dc.contributor.author Woo, Dong-Cheol ko
dc.contributor.author Kim, Young Ro ko
dc.contributor.author Kim, Jeong Kon ko
dc.date.available 2015-05-26T03:22:46Z -
dc.date.created 2015-05-20 ko
dc.date.issued 2015-06 ko
dc.identifier.citation NMR IN BIOMEDICINE, v.28, no.6, pp.624 - 632 ko
dc.identifier.issn 0952-3480 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/11527 -
dc.description.abstract Exploiting ultrashort-T<inf>E</inf> (UTE) MRI, T<inf>1</inf>-weighted positive contrast can be obtained from superparamagnetic iron oxide nanoparticles (SPIONs), which are widely used as a robust T<inf>2</inf>-weighted, negative contrast agent on conventional MR images. Our study was designed (a) to optimize the dual-contrast MRI method using SPIONs and (b) to validate the feasibility of simultaneously evaluating the vascular morphology, blood volume and transvascular permeability using the dual-contrast effect of SPIONs. All studies were conducted using 3T MRI. According to numerical simulation, 0.15mM was the optimal blood SPION concentration for visualizing the positive contrast effect using UTE MRI (T<inf>E</inf>=0.09ms), and a flip angle of 40° could provide sufficient SPION-induced enhancement and acceptable measurement noise for UTE MR angiography. A pharmacokinetic study showed that this concentration can be steadily maintained from 30 to 360min after the injection of 29mg/kg of SPIONs. An in vivo study using these settings displayed image quality and CNR of SPION-enhanced UTE MR angiography (image quality score 3.5; CNR 146) comparable to those of the conventional, Gd-enhanced method (image quality score 3.8; CNR 148) (p>0.05). Using dual-contrast MR images obtained from SPION-enhanced UTE and conventional spin- and gradient-echo methods, the transvascular permeability (water exchange index 1.76-1.77), cerebral blood volume (2.58-2.60%) and vessel caliber index (3.06-3.10) could be consistently quantified (coefficient of variation less than 9.6%; Bland-Altman 95% limits of agreement 0.886-1.111) and were similar to the literature values. Therefore, using the optimized setting of combined SPION-based MRI techniques, the vascular morphology, blood volume and transvascular permeability can be comprehensively evaluated during a single session of MR examination. ⓒ 2015 John Wiley & Sons, Ltd ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher WILEY-BLACKWELL ko
dc.title Simultaneous evaluation of vascular morphology, blood volume and transvascular permeability using SPION-based, dual-contrast MRI: Imaging optimization and feasibility test ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84929294999 ko
dc.identifier.wosid 000354416300003 ko
dc.type.rims ART ko
dc.description.wostc 0 *
dc.description.scopustc 0 *
dc.date.tcdate 2015-12-28 *
dc.date.scptcdate 2015-10-28 *
dc.identifier.doi 10.1002/nbm.3293 ko
dc.identifier.url http://onlinelibrary.wiley.com/doi/10.1002/nbm.3293/abstract ko
Appears in Collections:
BME_Journal Papers
Files in This Item:
There are no files associated with this item.

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show simple item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU