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Cho, Hyungjoon
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dc.citation.endPage 632 -
dc.citation.number 6 -
dc.citation.startPage 624 -
dc.citation.title NMR IN BIOMEDICINE -
dc.citation.volume 28 - Kwon, Heon-Ju - Shim, Woo Hyun - Cho, Gyunggoo - Cho, Hyungjoon - Jung, Hoe Su - Lee, Chang Kyung - Lee, Yong Seok - Baek, Jin Hee - Kim, Eun Ju - Suh, Ji-Yeon - Sung, Yu Sub - Woo, Dong-Cheol - Kim, Young Ro - Kim, Jeong Kon - 2023-12-22T01:11:53Z - 2023-12-22T01:11:53Z - 2015-05-20 - 2015-06 -
dc.description.abstract Exploiting ultrashort-TE (UTE) MRI, T1-weighted positive contrast can be obtained from superparamagnetic iron oxide nanoparticles (SPIONs), which are widely used as a robust T2-weighted, negative contrast agent on conventional MR images. Our study was designed (a) to optimize the dual-contrast MRI method using SPIONs and (b) to validate the feasibility of simultaneously evaluating the vascular morphology, blood volume and transvascular permeability using the dual-contrast effect of SPIONs. All studies were conducted using 3T MRI. According to numerical simulation, 0.15mM was the optimal blood SPION concentration for visualizing the positive contrast effect using UTE MRI (TE=0.09ms), and a flip angle of 40° could provide sufficient SPION-induced enhancement and acceptable measurement noise for UTE MR angiography. A pharmacokinetic study showed that this concentration can be steadily maintained from 30 to 360min after the injection of 29mg/kg of SPIONs. An in vivo study using these settings displayed image quality and CNR of SPION-enhanced UTE MR angiography (image quality score 3.5; CNR 146) comparable to those of the conventional, Gd-enhanced method (image quality score 3.8; CNR 148) (p>0.05). Using dual-contrast MR images obtained from SPION-enhanced UTE and conventional spin- and gradient-echo methods, the transvascular permeability (water exchange index 1.76-1.77), cerebral blood volume (2.58-2.60%) and vessel caliber index (3.06-3.10) could be consistently quantified (coefficient of variation less than 9.6%; Bland-Altman 95% limits of agreement 0.886-1.111) and were similar to the literature values. Therefore, using the optimized setting of combined SPION-based MRI techniques, the vascular morphology, blood volume and transvascular permeability can be comprehensively evaluated during a single session of MR examination. ⓒ 2015 John Wiley & Sons, Ltd -
dc.identifier.bibliographicCitation NMR IN BIOMEDICINE, v.28, no.6, pp.624 - 632 -
dc.identifier.doi 10.1002/nbm.3293 -
dc.identifier.issn 0952-3480 -
dc.identifier.scopusid 2-s2.0-84929294999 -
dc.identifier.uri -
dc.identifier.url -
dc.identifier.wosid 000354416300003 -
dc.language 영어 -
dc.publisher WILEY-BLACKWELL -
dc.title Simultaneous evaluation of vascular morphology, blood volume and transvascular permeability using SPION-based, dual-contrast MRI: Imaging optimization and feasibility test -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.relation.journalWebOfScienceCategory Biophysics; Radiology, Nuclear Medicine & Medical Imaging; Spectroscopy -
dc.relation.journalResearchArea Biophysics; Radiology, Nuclear Medicine & Medical Imaging; Spectroscopy -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordAuthor dual contrast -
dc.subject.keywordAuthor superparamagnetic iron oxide nanoparticles -
dc.subject.keywordAuthor ultrashort T-E imaging -
dc.subject.keywordAuthor water exchange index -
dc.subject.keywordAuthor blood volume -
dc.subject.keywordAuthor MR angiography -
dc.subject.keywordPlus MAGNETIC-RESONANCE -
dc.subject.keywordPlus ENHANCED MRI -
dc.subject.keywordPlus NANOPARTICLES -
dc.subject.keywordPlus FERUMOXYTOL -
dc.subject.keywordPlus ANGIOGENESIS -
dc.subject.keywordPlus AGENTS -
dc.subject.keywordPlus T-1 -
dc.subject.keywordPlus SUSCEPTIBILITY -
dc.subject.keywordPlus THERAPY -


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