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Lim, Mi Hee
MetalloNeuroChemistry Lab (MNCL)
Research Interests
  • Neurodegenerative disease, small molecule design, network between metal, proteins, and ROS

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Tools of the Trade: Investigations into Design Strategies of Small Molecules to Target Components in Alzheimer's Disease

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Title
Tools of the Trade: Investigations into Design Strategies of Small Molecules to Target Components in Alzheimer's Disease
Author
Derrick, Jeffrey S.Lim, Mi Hee
Issue Date
2015-04
Publisher
WILEY-V C H VERLAG GMBH
Citation
CHEMBIOCHEM, v.16, no.6, pp.887 - 898
Abstract
The growing prevalence of Alzheimer's disease (AD) has warranted the development of effective therapeutic methods. Current available drugs for AD (i.e., acetylcholinesterase (AChE) inhibitors and N-methyl-D-aspartate (NMDA) receptor antagonists) have only offered brief symptomatic relief. Considering that the numbers affected by AD are projected to substantially rise, long-term strategies are urgently needed. The multiple series of small molecules to combat AD have been expanded, with current methods taking aim at factors, such as misfolded protein accumulation, metal ion dyshomeostasis, and oxidative stress. This concept article focuses on describing the design of compounds to target various components of AD and underlining recent advances that have been made.
URI
https://scholarworks.unist.ac.kr/handle/201301/11127
URL
http://onlinelibrary.wiley.com/doi/10.1002/cbic.201402718/abstract
DOI
10.1002/cbic.201402718
ISSN
1439-4227
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PHY_Journal Papers
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