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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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O-GlcNAcase is essential for embryonic development and maintenance of genomic stability

Cited 37 times inthomson ciCited 40 times inthomson ci
Title
O-GlcNAcase is essential for embryonic development and maintenance of genomic stability
Author
Yang, Yong RyoulSong, MinseokLee, HoJeon, YoonChoi, Eun-JeongJang, Hyun-JunMoon, Hyo YoulByun, Ha-YoungKim, Eung-KyunKim, Dae HyunLee, Mi NamKoh, AraGhim, JaewangChoi, Jang HyunLee-Kwon, WhaseonKim, Kyong TaiRyu, Sung HoSuh, Pann-Ghill
Issue Date
2012-06
Publisher
WILEY-BLACKWELL
Citation
AGING CELL, v.11, no.3, pp.439 - 448
Abstract
Dysregulation of O-GlcNAc modification catalyzed by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) contributes to the etiology of chronic diseases of aging, including cancer, cardiovascular disease, type 2 diabetes, and Alzheimers disease. Here we found that natural aging in wild-type mice was marked by a decrease in OGA and OGT protein levels and an increase in O-GlcNAcylation in various tissues. Genetic disruption of OGA resulted in constitutively elevated O-GlcNAcylation in embryos and led to neonatal lethality with developmental delay. Importantly, we observed that serum-stimulated cell cycle entry induced increased O-GlcNAcylation and decreased its level after release from G2/M arrest, indicating that O-GlcNAc cycling by OGT and OGA is required for precise cell cycle control. Constitutively, elevated O-GlcNAcylation by OGA disruption impaired cell proliferation and resulted in mitotic defects with downregulation of mitotic regulators. OGA loss led to mitotic defects including cytokinesis failure and binucleation, increased lagging chromosomes, and micronuclei formation. These findings suggest an important role for O-GlcNAc cycling by OGA in embryonic development and the regulation of the maintenance of genomic stability linked to the aging process.
URI
https://scholarworks.unist.ac.kr/handle/201301/11002
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84860872762
DOI
10.1111/j.1474-9726.2012.00801.x
ISSN
1474-9718
Appears in Collections:
BIO_Journal Papers
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