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DC Field | Value | Language |
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dc.citation.endPage | 609 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 600 | - |
dc.citation.title | MACROMOLECULES | - |
dc.citation.volume | 48 | - |
dc.contributor.author | Son, Suhyun | - |
dc.contributor.author | Shin, Eeseul | - |
dc.contributor.author | Kim, Byeong-Su | - |
dc.date.accessioned | 2023-12-22T01:40:22Z | - |
dc.date.available | 2023-12-22T01:40:22Z | - |
dc.date.created | 2015-03-03 | - |
dc.date.issued | 2015-02 | - |
dc.description.abstract | Polymers that are biocompatible and degrade in response to stimuli are highly desirable as smart drug-delivery carriers. We report the first novel redox-degradable hyperbranched polyglycerols. A glycerol monomer containing a disulfide bond, i.e., 2-((2-(oxiran-2-ylmethoxy)ethyl)disulfanyl)ethan-1-ol (SSG), was designed and polymerized through anionic ring-opening multibranching polymerization to yield a series of redox-degradable hyperbranched polyglycerols (PSSGs) with controlled molecular weights (2000-11 000 g/mol) and relatively low molecular weight distributions (Mw/Mn < 1.15). In addition, copolymerization with a nondegradable glycerol (G) monomer provided P(G-co-SSG) copolymers, which contained an adjustable fraction of degradable moieties within their polyglycerol backbones. The polymerization was characterized using 1H and 13C NMR spectroscopy, GPC, and MALDI-ToF mass spectrometry. The copolymerization process was also evaluated using quantitative in situ 13C NMR kinetic measurements in bulk, which revealed that the reaction kinetics of G were faster than those of the SSG monomer, leading to a gradient during the copolymerization process. Furthermore, we explored the redox-responsive degradation of the polymers upon treatment with a reducing agent, which resulted in selective degradation of the polymers in small segments. In vitro cytotoxicity studies, such as MTT and CCK-8 assays, revealed the superior biocompatibility of these new polymers even at high concentrations of 500 μg/mL. We anticipate that these novel redox-degradable and highly biocompatible polyglycerols will find applications in a variety of emerging biomedical fields. | - |
dc.identifier.bibliographicCitation | MACROMOLECULES, v.48, no.3, pp.600 - 609 | - |
dc.identifier.doi | 10.1021/ma502242v | - |
dc.identifier.issn | 0024-9297 | - |
dc.identifier.scopusid | 2-s2.0-84922611748 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/10763 | - |
dc.identifier.url | http://pubs.acs.org/doi/abs/10.1021/ma502242v | - |
dc.identifier.wosid | 000349574100018 | - |
dc.language | 영어 | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Redox-degradable biocompatible hyperbranched polyglycerols: Synthesis, copolymerization kinetics, degradation, and biocompatibility | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | CROSS-LINKED MICELLES | - |
dc.subject.keywordPlus | BLOCK-COPOLYMERS | - |
dc.subject.keywordPlus | MULTIFUNCTIONAL POLYETHERS | - |
dc.subject.keywordPlus | SIDE-CHAINS | - |
dc.subject.keywordPlus | GLUTATHIONE | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | DENDRIMERS | - |
dc.subject.keywordPlus | POLYMERS | - |
dc.subject.keywordPlus | SMART | - |
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