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정웅규

Jung, Woonggyu
Translational Biophotonics Lab.
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Investigation of bacterial biofilm in the human middle ear using optical coherence tomography and acoustic measurements

Author(s)
Nguyen, Cac T.Robinson, Sarah R.Jung, WoonggyuNovak, Michael A.Boppart, Stephen A.Allen, Jont B.
Issued Date
2013-07
DOI
10.1016/j.heares.2013.04.001
URI
https://scholarworks.unist.ac.kr/handle/201301/10328
Citation
HEARING RESEARCH, v.301, pp.193 - 200
Abstract
Children with chronic otitis media (OM) often have conductive hearing loss which results in communication
difficulties and requires surgical treatment. Recent studies have provided clinical evidence that
there is a one-to-one correspondence between chronic OM and the presence of a bacterial biofilm behind
the tympanic membrane (TM). Here we investigate the acoustic effects of bacterial biofilms, confirmed
using optical coherence tomography (OCT), in adult ears. Non-invasive OCT images are collected to
visualize the cross-sectional structure of the middle ear, verifying the presence of a biofilm behind the
TM. Wideband measurements of acoustic reflectance and impedance (0.2e6 [kHz]) are used to study the
acoustic properties of ears with confirmed bacterial biofilms. Compared to known acoustic properties of
normal middle ears, each of the ears with a bacterial biofilm has an elevated power reflectance in the 1 to
3 [kHz] range, corresponding to an abnormally small resistance (real part of the impedance). These
results provide assistance for the clinical diagnosis of a bacterial biofilm, which could lead to improved
treatment of chronic middle ear infection and further understanding of the impact of chronic OM on
conductive hearing loss
Publisher
ELSEVIER SCIENCE BV
ISSN
0378-5955
Keyword
CONDUCTIVE HEARING-LOSSOTITIS-MEDIAREFLECTANCE MEASUREMENTSENERGY REFLECTANCECANAL REFLECTANCEUMBO VELOCITYIN-VIVODISEASEMUCOSATYMPANOMETRY

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