Full metadata record
DC Field | Value | Language |
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dc.citation.endPage | 10 | - |
dc.citation.number | Suppl 9 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | BMC GENOMICS | - |
dc.citation.volume | 15 | - |
dc.contributor.author | Jun, JeHoon | - |
dc.contributor.author | Cho, Yun Sung | - |
dc.contributor.author | Hu, Haejin | - |
dc.contributor.author | Kim, Hak-Min | - |
dc.contributor.author | Jho, Sungwoong | - |
dc.contributor.author | Gadhvi, Priyvrat | - |
dc.contributor.author | Park, Kyung Mi | - |
dc.contributor.author | Lim, Jeongheui | - |
dc.contributor.author | Paek, Woon Kee | - |
dc.contributor.author | Han, Kyudong | - |
dc.contributor.author | Manica, Andrea | - |
dc.contributor.author | Edwards, Jeremy S. | - |
dc.contributor.author | Bhak, Jong Hwa | - |
dc.date.accessioned | 2023-12-22T01:48:16Z | - |
dc.date.available | 2023-12-22T01:48:16Z | - |
dc.date.created | 2015-01-19 | - |
dc.date.issued | 2014-12 | - |
dc.description.abstract | Background: The horse (Equus ferus caballus) is one of the earliest domesticated species and has played an important role in the development of human societies over the past 5,000 years. In this study, we characterized the genome of the Marwari horse, a rare breed with unique phenotypic characteristics, including inwardly turned ear tips. It is thought to have originated from the crossbreeding of local Indian ponies with Arabian horses beginning in the 12th century. Results: We generated 101 Gb (similar to 30 x coverage) of whole genome sequences from a Marwari horse using the Illumina HiSeq2000 sequencer. The sequences were mapped to the horse reference genome at a mapping rate of similar to 98% and with similar to 95% of the genome having at least 10 x coverage. A total of 5.9 million single nucleotide variations, 0.6 million small insertions or deletions, and 2,569 copy number variation blocks were identified. We confirmed a strong Arabian and Mongolian component in the Marwari genome. Novel variants from the Marwari sequences were annotated, and were found to be enriched in olfactory functions. Additionally, we suggest a potential functional genetic variant in the TSHZ1 gene (p.Ala344>Val) associated with the inward-turning ear tip shape of the Marwari horses. Conclusions: Here, we present an analysis of the Marwari horse genome. This is the first genomic data for an Asian breed, and is an invaluable resource for future studies of genetic variation associated with phenotypes and diseases in horses. |
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dc.identifier.bibliographicCitation | BMC GENOMICS, v.15, no.Suppl 9, pp.1 - 10 | - |
dc.identifier.doi | 10.1186/1471-2164-15-S9-S4 | - |
dc.identifier.issn | 1471-2164 | - |
dc.identifier.scopusid | 2-s2.0-84939532022 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/10186 | - |
dc.identifier.wosid | 000346166300005 | - |
dc.language | 영어 | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.title | Whole genome sequence and analysis of the Marwari horse breed and its genetic origin | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology; Genetics & Heredity | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology; Genetics & Heredity | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | MULTILOCUS GENOTYPE DATA | - |
dc.subject.keywordPlus | WIDE SNP-ASSOCIATION | - |
dc.subject.keywordPlus | COAT COLOR | - |
dc.subject.keywordPlus | POPULATION-STRUCTURE | - |
dc.subject.keywordPlus | MISSENSE MUTATION | - |
dc.subject.keywordPlus | MAXIMUM-LIKELIHOOD | - |
dc.subject.keywordPlus | SPOTTINGPATTERN | - |
dc.subject.keywordPlus | QUARTER HORSE | - |
dc.subject.keywordPlus | KIT GENE | - |
dc.subject.keywordPlus | VARIANT | - |
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