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DC Field | Value | Language |
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dc.citation.endPage | 740 | - |
dc.citation.number | 13-14 | - |
dc.citation.startPage | 733 | - |
dc.citation.title | LIFE SCIENCES | - |
dc.citation.volume | 82 | - |
dc.contributor.author | Lim, Seyoung | - |
dc.contributor.author | Choi, Jung Woong | - |
dc.contributor.author | Kim, Hyeon Soo | - |
dc.contributor.author | Kim, Yun-Hee | - |
dc.contributor.author | Yea, Kyungmoo | - |
dc.contributor.author | Heo, Kyan | - |
dc.contributor.author | Kim, Jong Hyun | - |
dc.contributor.author | Kim, Sun-Hee | - |
dc.contributor.author | Song, Minseok | - |
dc.contributor.author | Il Kim, Jae | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.date.accessioned | 2023-12-22T08:43:20Z | - |
dc.date.available | 2023-12-22T08:43:20Z | - |
dc.date.created | 2015-01-12 | - |
dc.date.issued | 2008-03 | - |
dc.description.abstract | Mast cells play a central role in allergic disease and host defense against several pathogens through the release of various bioactive compounds via degranulation. In this study, we found that a myristoylated pseudosubstrate of PKC-zeta (zeta-PS; myristoyl-SIYRRGARRWRKL, a PKC-zeta inhibitor) regulates mast cell degranulation. zeta-PS increased [Ca+2](i) level at nanomolar concentrations in a PKC-zeta activity-independent manner in HMC-1 cells. Moreover, zeta-PS-induced [Ca+2](i) generation was completely abrogated by phospholipase C (PLC), IP3 receptor or G alpha(i/o). inhibitor and zeta-PS potently induced degranulation in HMC-1 cells which was significantly inhibited by pretreating PLC inhibitors or a calcium chelator. Therefore, our results suggest that zeta-PS can induce degranulation in HMC-1 cells by triggering the calcium signal via a PKC-zeta-independent but G alpha(i/o), PLC and IP3-dependent pathways. (c) 2008 Elsevier Inc. All rights reserved. | - |
dc.identifier.bibliographicCitation | LIFE SCIENCES, v.82, no.13-14, pp.733 - 740 | - |
dc.identifier.doi | 10.1016/j.lfs.2008.01.005 | - |
dc.identifier.issn | 0024-3205 | - |
dc.identifier.scopusid | 2-s2.0-40849094196 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/10098 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=40849094196 | - |
dc.identifier.wosid | 000254691700008 | - |
dc.language | 영어 | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | A myristoylated pseudosubstrate peptide of PKC-zeta induces degranulation in HMC-1 cells independently of PKC-zeta activity | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | zeta-PS | - |
dc.subject.keywordAuthor | mast cells | - |
dc.subject.keywordAuthor | calcium | - |
dc.subject.keywordAuthor | phospholipase C | - |
dc.subject.keywordAuthor | IP3 | - |
dc.subject.keywordAuthor | degranulation | - |
dc.subject.keywordPlus | PERITONEAL MAST-CELLS | - |
dc.subject.keywordPlus | HISTAMINE-RELEASE | - |
dc.subject.keywordPlus | HOST-DEFENSE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | EFFECTOR | - |
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