https://scholarworks.unist.ac.kr/handle/201301/14 Wed, 13 May 2026 10:26:21 GMT 2026-05-13T10:26:21Z https://scholarworks.unist.ac.kr/handle/201301/91662 Title: Cryogenic TDS Platform for Quantitative Hydrogen Isotope (H2/D2/HD) Separation via Quantum Sieving in Porous Materials Author(s): Jung, Minji; Kim, Hyunlim; Hirscher, Michael; Oh, Hyunchul Abstract: Accurate evaluation of hydrogen isotope separation performance is critical for the development of advanced porous materials for energy, semiconductor, and nuclear applications. Herein, we report the development of an advanced cryogenic thermal desorption spectroscopy (AC-TDS) platform capable of quantitatively analyzing hydrogen isotopes (H2, D2, and even HD) over a wide temperature range (15 ? 900 K). The system incorporates calibration standards such as TiH2 and Pd95Ce5 alloy, enabling reliable quantification of desorbed gases. By varying the gas exposure temperature, time, and pressure, we can elucidate the microscopic nature of adsorption processes associated with structural flexibility, pore accessibility, or strong adsorption sites. With binary (H2/D2) and ternary (H2/HD/D2) isotope gas mixtures, AC-TDS directly determines isotope-dependent uptakes and selectivities using small quantities of samples and extracts desorption energetics via multi-rate analysis. Using specific gas exposure conditions, the TDS technique offers a powerful diagnostic tool for understanding adsorption energetics, framework dynamics, and isotope selectivity, and allows a rapid characterization of porous materials for hydrogen isotope separation applications based on selective adsorption. Thu, 30 Apr 2026 15:00:00 GMT https://scholarworks.unist.ac.kr/handle/201301/91662 2026-04-30T15:00:00Z https://scholarworks.unist.ac.kr/handle/201301/91653 Title: Stimuli-Responsive Zirconium-Based Metal-Organic Frameworks for Targeted Cancer Drug Delivery Author(s): Ghosh, Riya; Hasan, Md Sajid; Gothwal, Suraj; Lee, Jaewoo; Dhasaiyan, Prabhu; Ryu, Ja-Hyoung Abstract: Metal-organic frameworks (MOFs) have emerged as versatile nanoplatforms for cancer drug delivery owing to their exceptionally high porosity, tunable pore architecture, modular composition, and flexible surface chemistry. In particular, zirconium-based MOFs (Zr-MOFs) have gained considerable attention owing to their good chemical stability, favorable biocompatibility, and ease of functional modification through coordination interactions. These attributes enable precise control over drug loading, surface functionalization, and stimulus-triggered release behavior. Recent advances in stimuli-responsive Zr-MOFs have enabled precise and tumor-selective drug delivery by utilizing intrinsic features of the tumor microenvironment (TME), such as acidic pH, redox gradients, elevated ATP levels, abnormal enzyme activity, and ionic variations, along with externally applied triggers, including light, heat, and ultrasound. This review presents a comprehensive and systematic overview of endogenous, exogenous, and multistimuli-responsive Zr-MOF nanoplatforms for targeted cancer drug delivery. We discuss key Zr-MOF structural families, design strategies for stimulus-responsive behavior, and the underlying structure-stimulus-function relationships that govern therapeutic performance. Representative examples are critically analyzed with respect to drug loading capacity, release mechanisms, targeting strategies, and in vitro and in vivo anticancer efficacy. Additionally, current limitations, including biosafety concerns, degradation behavior, tumor heterogeneity, and barriers to clinical translation, are addressed. Finally, future perspectives are outlined to support the rational development of next-generation Zr-MOF-based nanomedicines with improved precision, controllability, and clinical applicability. Tue, 31 Mar 2026 15:00:00 GMT https://scholarworks.unist.ac.kr/handle/201301/91653 2026-03-31T15:00:00Z https://scholarworks.unist.ac.kr/handle/201301/91652 Title: Targeted Supramolecular Senolytics by Enzyme-Responsive Disassembly and Intracellular Polymerization Author(s): Kim, Sangpil; Lee, Jaeeun; Cho, Yumi; Park, Hyun-Seo; Oh, Seung Hak; Kim, Jiye; Kim, Dohyun; Sim, Youjung; Seu, Min-Seok; Kim, Chaekyu; Kwak, Sang Kyu; Ryu, Ja-Hyoung Abstract: Recent evidence indicates that elimination of senescent cells from tissue can be a therapeutic approach to treat age-related disease, but selective targeting of senescent cells remains a challenge. Here, we report a dual-responsive self-assembly system selectively targeting senescent cells by responding to two hallmark features: elevated reactive oxygen species levels and increased alkaline phosphatase (ALP) activity. The engineered monomer (p-Mito-1), bearing phosphate-protected thiol groups and mitochondrial-targeting moieties, assembles into zwitterionic bioinactive spherical nanostructures with low membrane affinity. In senescent cells, ALP-mediated dephosphorylation of p-Mito-1 triggers disassembly and mitochondrial accumulation of the deprotected monomer (Mito-1), followed by ROS-induced transformation into bioactive fiber structures via disulfide bond formation. This morphological transition exposes surface positive charges, facilitating mitochondrial membrane disruption and the selective activation of apoptosis in senescent cells. In vitro, p-Mito-1 showed selective cytotoxicity toward senescent RPE (SnC_RPE; IC50 approximate to 80 mu M) with negligible effects on normal RPE even at 200 mu M. We further validated efficacy in an AMD-relevant model, where localized administration selectively depleted senescent RPE cells without overt local toxicity. Our findings demonstrate the potential of dual-responsive supramolecular systems for precise targeting of senescent cells and highlight a modular design strategy for aging-related disease intervention. Wed, 31 Dec 2025 15:00:00 GMT https://scholarworks.unist.ac.kr/handle/201301/91652 2025-12-31T15:00:00Z https://scholarworks.unist.ac.kr/handle/201301/91650 Title: B-Site Engineering in Ruddlesden-Popper Perovskites (A2BO4) for H2O2 Production with 4.85% of Solar-to-Chemical Efficiency Author(s): Cho, Jaewon; Choi, Jun-Yong; Jeong, Eunjae; Yu, Je Min; Kim, Youngchul; Lee, Hyunjoo; Lee, Sang-Goo; Lee, Geunsik; Jang, Ji-Wook; Jo, Wook Abstract: The electrochemical synthesis of hydrogen peroxide (H2O2) via the oxygen reduction reaction (ORR) offers a promising alternative to the anthraquinone process, addressing environmental concerns without requiring expensive hydrogen. However, developing catalysts that selectively promote the two-electron ORR pathway while maintaining stability remains challenging. Here, we report Ruddlesden-Popper (RP) perovskite oxides as efficient catalysts for selective H2O2 production. Among the tested LaSrBO4 compositions (B = Ni, Co, Fe, Mn), LaSrNiO4 (LSN) showed the best two-electron ORR selectivity (similar to 87%) and activity. Integrated into a photovoltaic-electrochemical system, LSN achieved a solar-to-chemical conversion efficiency of 4.85%, producing a H2O2 production rate of 149.2 mu mol cm(-2) h(-1) with good stability over 50 h. Density functional theory calculations attributed this performance to favorable H2O2 formation and desorption kinetics at the Ni B-site. Overall, RP perovskites offer earth-abundant, efficient, and sustainable catalysts for electrochemical H2O2 generation, providing an alternative to carbon- or noble-metal-based systems. Tue, 31 Mar 2026 15:00:00 GMT https://scholarworks.unist.ac.kr/handle/201301/91650 2026-03-31T15:00:00Z