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A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms File

Derrick, Jeffrey S. , Kerr, Richard A. , Nam, Younwoo , Oh, Shin Bi , Lee, Hyuck Jin , Earnest, Kaylin G. , Suh, Nayoung , Peck, Kristy L. , Ozbil, Mehmet , Korshavn, Kyle J. , et al

Article Issue Date2015-11 View89

A small molecule that displays marked reactivity toward copper-versus zinc-amyloid-β implicated in Alzheimer's disease File

Savelieff, Masha G. , Liu, Yuzhong , Senthamarai, Russell R. P. , Korshavn, Kyle J. , Lee, Hyuck Jin , Ramamoorthy, Ayyalusamy , Lim, Mi Hee

Article Issue Date2014-05 View123

Amyloid-beta adopts a conserved, partially folded structure upon binding to zwitterionic lipid bilayers prior to amyloid formation File

Lim, Mi Hee , Korshavn, Kyle J. , Ramamoorthy, Ayyalusamy , Bhunia, Anirban

Article Issue Date2016-01 View57

An Iridium(III) Complex as a Photoactivatable Tool for Oxidation of Amyloidogenic Peptides with Subsequent Modulation of Peptide Aggregation File

Kang, Juhye , Lee, Shin Jung C. , Nam. Jung Seung , Lee, Hyuck Jin , Kang, Mueong-G. , Korshavn, Kyle J. , Kim, Hyun-Tak , Cho, Jaeheung , Ramamoorthy, Ayyalusamy , Rhee, Hyun-Woo , et al

Article Issue Date2017-01 View165

AN IRIDIUM(III) COMPLEX AS A PHOTOACTIVATABLE TOOL FOR OXIDATION OF AMYLOIDOGENIC PEPTIDES WITH SUBSEQUENT MODULATION OF PEPTIDE AGGREGATION

Kang, Juhye , Lee, Shin Jung C , Nam, Jung Seung , Lee, Hyuck Jin , Korshavn, Kyle J. , Kim, Hyun-Tak , Cho, Jaeheung , Ramamoorthy, Ayyalusamy , Rhee, Hyun-Woo , Kwon, Tae-Hyuk , et al

Conference Paper Issue Date2016-12-05 View33

Biophysical insights into the membrane interaction of the core amyloid-forming A beta(40) fragment K16-K28 and its role in the pathogenesis of Alzheimer's disease File

Bera, Swapna , Korshavn, KJ , Kar, Rajjiv K. , Lim, Mi Hee , Ramamoorthy, Ayyalusamy , Bhunia, Anirban

Article Issue Date2016-07 View35

Design of small molecules that target metal-A beta species and regulate metal-induced A beta aggregation and neurotoxicity File

Choi, Jung-Suk , Braymer, Joseph J. , Nanga, Ravi P. R. , Ramamoorthy, Ayyalusamy , Lim, Mi Hee

Article Issue Date2010-12 View47

Development of Bifunctional Stilbene Derivatives for Targeting and Modulating Metal-Amyloid-beta Species File

Braymer, Joseph J. , Choi, Jung-Suk , DeToma, Alaina S. , Wang, Chen , Nam, Kisoo , Kampf, Jeffrey W. , Ramamoorthy, Ayyalusamy , Lim, Mi Hee

Article Issue Date2011-11 View61

Diverse Structural Conversion and Aggregation Pathways of Alzheimer's Amyloid-beta (1-40) File

Lin, Yuxi , Sahoo, Bikash R. , Ozawa, Daisaku , Kinoshita, Misaki , Kang, Juhye , Lim, Mi Hee , Okumura, Masaki , Huh, Yang Hoon , Moon, Eunyoung , Jang, Jae Hyuck , et al

Article Issue Date2019-08 View51

DLPC Liposomes Inhibit A beta Fibrillation and Remodel Preformed Fibrils Through a Detergent-like Mechanism

Korshavn, Kyle , Satriano, Cristina , Zhang, Rongchun , Dulchavsky, Mark , Bhunia, Anirban , Ivanova, Magdalena , La Rosa, Carmelo , Lim, Mi Hee , Ramamoorthy, Ayyalusamy

Conference Paper Issue Date2016-07-16 View18

Dual-function triazole-pyridine derivatives as inhibitors of metal-induced amyloid-beta aggregation File

Jones, Michael R. , Service, Erin L. , Thompson, John R. , Wang, Michael C. P. , Kimsey, Isaac J. , DeToma, Alaina S. , Ramamoorthy, Ayyalusamy , Lim, Mi Hee , Storr, Tim

Article Issue Date2012-08 View52

Effects of hydroxyl group variations on a flavonoid backbone toward modulation of metal-free and metal-induced amyloid-β aggregation File File

Lee, Hyuckjin , Kerr, Richard A. , Korshavn, Kyle J. , Lee, Jeeyeon , Kang, Juhye , Ramamoorthy, Ayyalusamy , Ruotolo, Brandon T. , Lim, Mi Hee

Article Issue Date2016-03 View61

Effects of Variable Hydroxyl Groups on the Flavonoid Backbone toward Modulation of Metal–Amyloid-Beta Aggregation Pathways

Lim, Mi Hee , Lee, Hyuck Jin , Kerr, Richard A. , Korshavn, Kyle J. , Lee, Jeeyeon , Ramamoorthy, Ayyalusamy , Ruotolo, Brandon T.

Conference Paper Issue Date2015-08-12 View14

Importance of the Dimethylamino Functionality on a Multifunctional Framework for Regulating Metals, Amyloid-beta, and Oxidative Stress in Alzheimer's Disease File

Derrick, Jeffry S. , Kerr, Richard A. , Korshavn, Kyle J. , McLane, Michael J. , Kang, Juhye , Nam, Eunju , Ramamoorthy, Ayyalusamy , Ruotolo, Brandon T. , Lim, Mi Hee

Article Issue Date2016-05 View32

Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-beta species File

Hyung, Suk-Joon , DeToma, Alaina S. , Brender, Jeffrey R. , Lee, Sanghyun , Vivekanandan, Subramanian , Kochi, Akiko , Choi, Jung-Suk , Ramamoorthy, Ayyalusamy , Ruotolo, Brandon T. , Lim, Mi Hee

Article Issue Date2013-03 View76

Interaction and reactivity of synthetic aminoisoflavones with metal-free and metal-associated amyloid-β File

Detoma, Alaina S. , Krishnamoorthy, Janarthanan , Nam, Younwoo , Lee, Hyuck Jin , Brender, Jeffrey R. , Kochi, Akiko , Lee, Dongkuk , Onnis, Valentina , Congiu, Cenzo , Manfredini, Stefano , et al

Article Issue Date2014-12 View74

Minor Structural Variations of Small Molecules Tune Regulatory Activities Towards Pathological Factors in Alzheimer’s Disease File

Beck, Michael W. , Derrick, Jeffrey S. , Suh, Jong-Min , Kim, Mingeun , Korshavn, Kyle J. , Kerr, Richard A. , Cho, Woo Jong , Larsen, Scott D. , Ruotolo, Brandon T. , Ramamoorthy, Ayyalusamy , et al

Article Issue Date2017-11 View50

Misfolded proteins in Alzheimer's disease and type II diabetes File

DeToma, Alaina S. , Salamekh, Samer , Ramamoorthy, Ayyalusamy , Lim, Mi Hee

Article Issue Date2012-01 View54

Multi-target-directed phenol-triazole ligands as therapeutic agents for Alzheimer's disease File File

Jones, Michael R. , Mathieu, Emilie , Dyrager, Christine , Faissner, Simon , Vaillancourt, Zavier , Korshavn, Kyle J. , Lim, Mi Hee , Ramamoorthy, Ayyalusamy , Yong, V. Wee , Tsutsui, Shigeki , et al

Article Issue Date2017-08 View27

Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease File

Lee, Sanghyun , Zheng, Xueyun , Krishnamoorthy, Janarthanan , Savelieff, Masha G. , Park, Hyun Min , Brender, Jeffrey R. , Kim, Jin Hoon , Derrick, Jeffrey S. , Kochi, Akiko , Lee, Hyuck Jin , et al

Article Issue Date2014-01 View156

Reactivity of Metal-Free and Metal-Associated Amyloid-β with Glycosylated Polyphenols and Their Esterified Derivatives File File

Korshavn, Kyle J. , Jang, Milim , Kwak, Yeon Ju , Kochi, Akiko , Vertuani, Silvia , Bhunia, Anirban , Manfredini, Stefano , Ramamoorthy, Ayyalusamy , Lim, Mi Hee

Article Issue Date2015-12 View60

Reduced lipid bilayer thickness regulates the aggregation and cytotoxicity of amyloid-β File

Korshavn, Kyle J. , Satriano, Cristina , Lin, Yuxi , Zhang, Rongchun , Dulchavsky, Mark , Bhunia, Anirban , Ivanova, Magdalena I. , Lee, Young-Ho , Rosa, Carmelo La , Lim, Mi Hee , et al

Article Issue Date2017-03 View25

Small Molecule Modulators of Copper-Induced A beta Aggregation File

Hindo, Sarmad S. , Mancino, Allana M. , Braymer, Joseph J. , Liu, Yihong , Vivekanandan, Subramanian , Ramamoorthy, Ayyalusamy , Lim, Mi Hee

Article Issue Date2009-11 View44

Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-Related Pathological Features in Alzheimer’s Disease

Lee, Hyuck Jin , Korshavn, Kyle J , Nam, Younwoo , Paul, Thomas J. , Kerr, Richard A , Youn, Il Seung , Kang, Juhye , Ozbil, Mehmet , Kim, Kwang S. , Ruotolo, Brandon T , et al

Conference Paper Issue Date2017-08-16 View16

Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-Related Pathological Features in Alzheimer’s Disease

Lee, Hyuck Jin , Korshavn, Kyle J. , Nam, Younwoo , Paul, Thomas J. , Kerr, Richard A. , Youn, Il Seung , Kang, Juhye , Ozbil, Mehmet , Kim, Kwang S. , Ruotolo, Brandon T. , et al

Conference Paper Issue Date2017-07-19 View18

Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-related Pathological Features in Alzheimer’s Disease File

Lee, Hyuck Jin , Korshavn, Kyle J. , Nam, Younwoo , Kang, Juhye , Paul, Thomas J. , Kerr, Richard A. , Youn, Il Seung , Ozbil, Mehmet , Kim, Kwang S. , Ruotolo, Brandon T. , et al

Article Issue Date2017-02 View32

Structural Characterization and Inhibition of Toxic Amyloid-beta Oligomeric Intermediates File

Ramamoorthy, Ayyalusamy , Lim, Mi Hee

Article Issue Date2013-07 View39

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