dc.citation.endPage |
855 |
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dc.citation.startPage |
843 |
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dc.citation.title |
JOURNAL OF GENERAL VIROLOGY |
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dc.citation.volume |
85 |
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dc.contributor.author |
Lim, Chunghun |
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dc.contributor.author |
Seo, Taegun |
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dc.contributor.author |
Jung, Jun |
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dc.contributor.author |
Choe, Joonho |
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dc.date.accessioned |
2023-12-22T11:06:39Z |
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dc.date.available |
2023-12-22T11:06:39Z |
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dc.date.created |
2015-01-05 |
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dc.date.issued |
2004-04 |
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dc.description.abstract |
Latency-associated nuclear antigen 1 (LANA1) of Kaposi's sarcoma-associated herpesvirus (KSHV) plays a pivotal role in the maintenance of the virus genome in latently infected cells. LANA1 links virus genomes to host chromosomes via a C-terminal DNA-binding domain which interacts with the sequences located in terminal repeats (TRs) of the virus genome and via an N-terminal chromosome-binding sequence which associates with the host chromosomes, respectively. Recent data suggest that LANA1 also actively participates in the replication of KSHV TR-containing plasmid in the transient DNA replication assay. In this report, it was found that C33A and COS-1, but not NIH/3T3, cell lines are permissive for the transient replication of KSHV TR-containing plasmid. Using several LANA1-deletion mutants, the minimum domain of LANA1 required for replication activity was also determined. In addition, the N terminus of LANA1 inhibited the transient replication systems of KSHV and Epstein-Barr virus (EBV) in transiently transfected 293 and 293T cells, but the C terminus of LANA1 specifically inhibited the transient replication system of KSHV in other cell lines. Consistent with previous reports, these data further emphasize the functional importance of the N terminus of LANA1 on replication from the KSHV latent origin of DNA replication. |
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dc.identifier.bibliographicCitation |
JOURNAL OF GENERAL VIROLOGY, v.85, pp.843 - 855 |
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dc.identifier.doi |
10.1099/vir.0.19510-0 |
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dc.identifier.issn |
0022-1317 |
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dc.identifier.scopusid |
2-s2.0-1842843635 |
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dc.identifier.uri |
https://scholarworks.unist.ac.kr/handle/201301/9837 |
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dc.identifier.url |
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=1842843635 |
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dc.identifier.wosid |
000220628700009 |
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dc.language |
영어 |
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dc.publisher |
SOC GENERAL MICROBIOLOGY |
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dc.title |
Identification of a virus trans-acting regulatory element on the latent DNA replication of Kaposi's sarcoma-associated herpesvirus |
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dc.type |
Article |
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dc.description.journalRegisteredClass |
scopus |
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