dc.citation.endPage |
6155 |
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dc.citation.number |
36 |
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dc.citation.startPage |
6146 |
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dc.citation.title |
ONCOGENE |
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dc.citation.volume |
23 |
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dc.contributor.author |
Seo, Taegun |
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dc.contributor.author |
Park, Junsoo |
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dc.contributor.author |
Lim, Chunghun |
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dc.contributor.author |
Choe, Joonho |
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dc.date.accessioned |
2023-12-22T10:44:13Z |
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dc.date.available |
2023-12-22T10:44:13Z |
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dc.date.created |
2015-01-05 |
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dc.date.issued |
2004-08 |
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dc.description.abstract |
Nuclear factor-kappaB (NF-kappaB) is a transcription factor that plays an important role in the immune system and cell death. Many viral proteins modulate NF-kappaB to escape host immune surveillance, promote cell survival, and enhance viral replication. In the present study, we show that NF-kappaB activity is downmodulated by viral interferon regulatory factor 3 (vIRF3), which is encoded by Kaposi's sarcoma-associated herpesvirus open-reading frame K10.5. vIRF3 repressed NF-kappaB-dependent transcription in a dose-dependent manner and inhibited the activation of NF-kappaB induced by tumor necrosis factor (TNF)-alpha. In vivo studies showed vIRF3 inhibited IkappaB kinase beta (IKKbeta) activity, but not IKKalpha activity, resulting in reduced IkappaB phosphorylation. Immunofluorescence assays showed that vIRF3 interfered with nuclear translocation of NF-kappaB. In addition, consistent with the inhibition of NF-kappaB activity, vIRF3 sensitized cells to TNF-alpha-induced apoptosis. While vIRF3 interacts with IKKbeta in vitro and in 293T cells, we were unable to demonstrate vIRF3-IKKbeta interaction in BCBL-1 cells. Our results indicate that vIRF3 can regulate the host immune system and apoptosis via inhibition of NF-kappaB activity. |
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dc.identifier.bibliographicCitation |
ONCOGENE, v.23, no.36, pp.6146 - 6155 |
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dc.identifier.doi |
10.1038/sj.onc.1207807 |
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dc.identifier.issn |
0950-9232 |
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dc.identifier.scopusid |
2-s2.0-4444279888 |
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dc.identifier.uri |
https://scholarworks.unist.ac.kr/handle/201301/9836 |
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dc.identifier.url |
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=4444279888 |
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dc.identifier.wosid |
000223261000014 |
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dc.language |
영어 |
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dc.publisher |
NATURE PUBLISHING GROUP |
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dc.title |
Inhibition of nuclear factor kappa B activity by viral interferon regulatory factor 3 of Kaposi's sarcoma-associated herpesvirus |
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dc.type |
Article |
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dc.description.journalRegisteredClass |
scopus |
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