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- Lee, Jiseok
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Biomimetic detection of aminoglycosidic antibiotics using polydiacetylene-phospholipids supramolecules
- Author(s)
- Kang, Do Hyun, Jung, Ho-Sup, Ahn, Namyoung, Lee, Jiseok, Seo, Sungbaek, Suh, Kahp-Yang, Kim, Jinsang, Kim, Keesung
- Issued Date
- 2012
- Citation
- CHEMICAL COMMUNICATIONS, v.48, no.43, pp.5313 - 5315
- Abstract
- We rationally designed highly sensitive and selective polydiacetylene (PDA)-phospholipids liposomes for the facile detection of aminoglycosidic antibiotics. The detecting mechanism mimics the cellular membrane interactions between neomycin and phosphatidylinositol-4,5-bisphosphate (PIP2) phospholipids. The developed PDA-PIP2 sensory system showed a detection limit of 61 ppb for neomycin and was very specific to aminoglycosidic antibodies only.
- Publisher
- ROYAL SOC CHEMISTRY
- ISSN
- 1359-7345
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