Fully Integrated Thermoplastic Genosensor for the Highly Sensitive Detection and Identification of Multi-Drug-Resistant Tuberculosis

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Fully Integrated Thermoplastic Genosensor for the Highly Sensitive Detection and Identification of Multi-Drug-Resistant Tuberculosis

Author(s): Wang, Hong, Chen, Hui-Wen, Hupert, Mateusz L., Chen, Pin-Chuan, Datta, Proyag, Pittman, Tana L., Goettert, Jost, Murphy, Michael C., Williams, Diana, Barany, Francis, Soper, Steven A.

Fulltext: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84860176902

Citation: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.51, no.18, pp.4349 - 4353

Abstract: A modular system for the reporting of drug-resistant strains of Mycobacterium tuberculosis (Mtb) in less than 30 min with full process automation was developed (see picture; MDR-TB=multi-drug-resistant tuberculosis). The fluidic cartridge uses a polymer chain reaction (PCR)/ligase detection reaction (LDR)/universal array assay that can detect, with high reliability, resistant strains that are a minority (less than 1%) from a mixed population.

Keyword: MYCOBACTERIUM-TUBERCULOSIS, DEVELOPING-COUNTRIES, MICROFLUIDIC CHIPS, POLY(METHYL METHACRYLATE), ANTIMICROBIAL RESISTANCE, RIFAMPIN RESISTANCE, POINT MUTATIONS, DNA, MICROARRAYS, DEVICES

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