dc.citation.endPage |
474 |
- |
dc.citation.number |
4 |
- |
dc.citation.startPage |
469 |
- |
dc.citation.title |
MOLECULES AND CELLS |
- |
dc.citation.volume |
10 |
- |
dc.contributor.author |
Lee, YH |
- |
dc.contributor.author |
Bae, SS |
- |
dc.contributor.author |
Seo, Jeong Kon |
- |
dc.contributor.author |
Choi, I |
- |
dc.contributor.author |
Ryu, SH |
- |
dc.contributor.author |
Suh, Pann-Ghill |
- |
dc.date.accessioned |
2023-12-22T12:07:06Z |
- |
dc.date.available |
2023-12-22T12:07:06Z |
- |
dc.date.created |
2014-11-19 |
- |
dc.date.issued |
2000-08 |
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dc.description.abstract |
Phospholipase C (PLC)-γ1 plays a pivotal role in the signal transduction pathway mediated by growth factors. In this study, we found that neurite outgrowth of pheochromocytoma (PC12) cells was significantly induced by interleukin-6 (IL-6). Stimulation of PC12 cells with IL-6 led to tyrosine phosphorylation of PLC-γ1 in a dose- and time-dependent manner. IL-6 stimulation also increased the hydrolysis of phosphatidylinositol 4,5-bisphosphate. Accumulation of total inositol phosphate as well as tyrosine phosphorylation of PLC-γ1 was inhibited by the pretreatment of protein kinase inhibitors such as genistein and staurosporine. These results suggest that PLC-γ1 may be involved in the signal transduction pathway of IL-6-induced PC12 cell differentiation. |
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dc.identifier.bibliographicCitation |
MOLECULES AND CELLS, v.10, no.4, pp.469 - 474 |
- |
dc.identifier.issn |
1016-8478 |
- |
dc.identifier.scopusid |
2-s2.0-0034738927 |
- |
dc.identifier.uri |
https://scholarworks.unist.ac.kr/handle/201301/9096 |
- |
dc.identifier.url |
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0034738927 |
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dc.identifier.wosid |
000088939500017 |
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dc.language |
영어 |
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dc.publisher |
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY |
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dc.title |
Interleukin-6-induced tyrosine phosphorylation of phospholipase C-gamma 1 in PC12 cells |
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dc.type |
Article |
- |
dc.description.journalRegisteredClass |
scopus |
- |