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Ryu, Ja-Hyoung
Supramolecular Nanomaterials Lab.
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Surface-Functionalizable Polymer Nanogels with Facile Hydrophobic Guest Encapsulation Capabilities

Author(s)
Ryu, Ja-HyoungJiwpanich, SiripornChacko, ReubenBickerton, SeanThayumanavan, S.
Issued Date
2010-06
DOI
10.1021/ja102316a
URI
https://scholarworks.unist.ac.kr/handle/201301/8922
Fulltext
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77953633752
Citation
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.132, no.24, pp.8246 - +
Abstract
The stability of encapsulation in self-assembly systems is limited during blood circulation because of a requisite concentration for assembly formation. For deliberate molecular design for stable encapsulation, targeting, and triggered release, we have developed a facile synthetic method for highly stable, polymeric nanogels using a simple intra/interchain cross-linking reaction. We show a simple, emulsion-free method for the preparation of biocompatible nanogels that provides the ability to encapsulate hydrophobic guest molecules and surface functionalization which has potential for targeted delivery. We show that the noncovalently encapsulated guest molecules can be released in response to a biologically relevant stimulus.
Publisher
AMER CHEMICAL SOC
ISSN
0002-7863

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