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DC Field | Value | Language |
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dc.citation.endPage | 16665 | - |
dc.citation.number | 46 | - |
dc.citation.startPage | 16663 | - |
dc.citation.title | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.citation.volume | 131 | - |
dc.contributor.author | Hindo, Sarmad S. | - |
dc.contributor.author | Mancino, Allana M. | - |
dc.contributor.author | Braymer, Joseph J. | - |
dc.contributor.author | Liu, Yihong | - |
dc.contributor.author | Vivekanandan, Subramanian | - |
dc.contributor.author | Ramamoorthy, Ayyalusamy | - |
dc.contributor.author | Lim, Mi Hee | - |
dc.date.accessioned | 2023-12-22T07:38:05Z | - |
dc.date.available | 2023-12-22T07:38:05Z | - |
dc.date.created | 2014-11-11 | - |
dc.date.issued | 2009-11 | - |
dc.description.abstract | (Chemical Equation Presented) Our design of bifunctional metal chelators as chemical probes and potential therapeutics for Alzheimer's disease (AD) is based on the incorporation of a metal binding moiety into structural frameworks of Aβ aggregate-imaging agents. Using this strategy, two compounds 2-[4-(dimethylamino)phenyl]imidazo[1,2-a]pyridine-8-ol (1) and N 1,N1-dimethyl-N4-(pyridin-2-ylmethylene) benzene-1,4-diamine (2) were prepared and characterized. The bifunctionality for metal chelation and Aβ interaction of 1 and 2 was verified by spectroscopic methods. Furthermore, the reactivity of 1 and 2 with Cu II-associated Aβ aggregates was investigated. The modulation of CuII-triggered Aβ aggregation by 1 and 2 was found to be more effective than that by the known metal chelating agents CQ, EDTA, and phen. These studies suggest a new class of multifunctional molecules for the development of chemical tools to unravel metal-associated events in AD and potential therapeutic agents for metal-ion chelation therapy. | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.131, no.46, pp.16663 - 16665 | - |
dc.identifier.doi | 10.1021/ja907045h | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.scopusid | 2-s2.0-70450202390 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/8622 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70450202390 | - |
dc.identifier.wosid | 000272185400030 | - |
dc.language | 영어 | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Small Molecule Modulators of Copper-Induced A beta Aggregation | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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