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- Kim, Chae Un
- High Pressure X-ray Science Lab.
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XFEL structure of carbonic anhydrase II: a comparative study of XFEL, NMR, X-ray and neutron structures
- Author(s)
- Hull, Joshua A., Lee, Cheol, Kim, Jin Kyun, Lim, Seon Woo, Park, Jaehyun, Park, Sehan, Lee, Sang Jae, Park, Gisu, Eom, Intae, Kim, Minseok, Hyun, HyoJung, Combs, Jacob E., Andring, Jacob T., Lomelino, Carrie, Kim, Chae Un, McKenna, Robert
- Issued Date
- 2024-03
- Citation
- ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, v.80, no.3, pp.194 - 202
- Abstract
- The combination of X-ray free-electron lasers (XFELs) with serial femtosecond crystallography represents cutting-edge technology in structural biology, allowing the study of enzyme reactions and dynamics in real time through the generation of 'molecular movies'. This technology combines short and precise high-energy X-ray exposure to a stream of protein microcrystals. Here, the XFEL structure of carbonic anhydrase II, a ubiquitous enzyme responsible for the interconversion of CO2 and bicarbonate, is reported, and is compared with previously reported NMR and synchrotron X-ray and neutron single-crystal structures.
- Publisher
- INT UNION CRYSTALLOGRAPHY
- ISSN
- 2059-7983
- Keyword (Author)
- X-ray crystallography, NMR, carbonic anhydrase II, XFELs, neutron diffraction crystallography, radiation damage
- Keyword
- CRYSTALLOGRAPHY, MECHANISM, DIOXIDE, RADIATION-DAMAGE, ACTIVE-SITE
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