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신흥주

Shin, Heungjoo
Micro/Nano Integrated Systems Lab.
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Microchannel-Integrated Sandwich 3D Triple Electrodes for Enhanced Detection of Myoglobin as a Cardiac Biomarker

Author(s)
Sharma, DeeptiLee, JongminShin, Heungjoo
Issued Date
2019-06-23
DOI
10.1109/TRANSDUCERS.2019.8808709
URI
https://scholarworks.unist.ac.kr/handle/201301/79622
Fulltext
https://ieeexplore.ieee.org/document/8808709
Citation
20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII, pp.1033 - 1035
Abstract
We report the development of an electrochemical redox cycling-based immunosensor using microchannel-integrated sandwich 3D triple electrode system. The triple electrodes consisting of a suspended carbon mesh and substrate-bound carbon interdigitated array (IDA) nanoelectrodes fabricated using C-MEMS. To complete an immunosensor a specific electrode was modified via the selective electrochemical reduction of aryl diazonium salts, and thus monoclonal antibody (mAb) could be immobilized on only suspended mesh electrode and the IDA electrodes were employed for the efficient redox-cycling of redox species (PAP/PQI). The microchannel integration facilitated 8-fold better low limit of detection (LOD) as compare to bulk, preventing diffusion of PAP to the bulk solution. © 2019 IEEE.
Publisher
Institute of Electrical and Electronics Engineers Inc.

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