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DC Field | Value | Language |
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dc.citation.conferencePlace | KO | - |
dc.citation.conferencePlace | 서울 COEX | - |
dc.citation.title | 2019 International Conference: Korean Society for Molecular and Cellular Biology | - |
dc.contributor.author | Lee, Byeong Eun | - |
dc.contributor.author | Kim, Hyun-Jin | - |
dc.contributor.author | Kim, Hye Yun | - |
dc.contributor.author | Lee, Ha-Eun | - |
dc.contributor.author | Lee, Jieun | - |
dc.contributor.author | Kim, Byung-Gyu | - |
dc.contributor.author | Myung, Kyungjae | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Kim, Jae-Ick | - |
dc.date.accessioned | 2024-01-31T23:39:00Z | - |
dc.date.available | 2024-01-31T23:39:00Z | - |
dc.date.created | 2019-12-22 | - |
dc.date.issued | 2019-10-01 | - |
dc.description.abstract | O-GlcNAcylation is one of pivotal post-translational modifications orchestrating fundamental cellular processes, including transcription, translation, and signal transduction. It attaches O-linked N-acetylglucosamine (O-GlcNAc) to serine, threonine residues of cytoplasmic, nuclear, and mitochondrial proteins. Since both O-GlcNAcylation and phosphorylation occur at the same residues, O-GlcNAcylation can compete or interact with phosphorylation in multiple cellular functions. Interestingly, O-GlcNAcylation and two enzymes governing O-GlcNAcylation are highly abundant in the brain. There have been reports showing the role of O-GlcNAcylation in modulating neuronal and synaptic properties. In addition, functional relevance of O-GlcNAcylation in neurological diseases has recently begun to emerge. Despite these findings, our understanding about the functional significance of O-GlcNAcylation in various brain systems and disorders remains rudimentary. We show that genetic manipulation of O-GlcNAc level in the dopamine system caused structural and functional changes. Furthermore, up-and down-regulation of OGlcNAcylation were associated with the corresponding alterations of mouse behaviors that are mediated by the dopamine system. These results demonstrate that O-GlcNAcylation may play a vital role in regulating structures and functions of dopamine system. | - |
dc.identifier.bibliographicCitation | 2019 International Conference: Korean Society for Molecular and Cellular Biology | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/79198 | - |
dc.language | 영어 | - |
dc.publisher | Korean Society for Molecular and Cellular Biology | - |
dc.title | The Physiological Role of O-Glcnacylation in the Dopamine System | - |
dc.type | Conference Paper | - |
dc.date.conferenceDate | 2019-09-30 | - |
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