Cloaking Protein Shield Zr-MOF Delivery Platform for Targeted Nanomedicine

Abstract

In this study, we intended to advance the possibilities of a Zr-MOF-based delivery platform by utilizing self-assembling bonds between the MOF active site and various carboxyl groups in functional shield proteins. Functional cloaking proteins such as GST-Afb (HER2 and EGFR) are very stable, inhibit reactions with other proteins and can be used for targeting. Such proteins can stabilize the active site of the MOF and also act as a targeting moiety. We effectively controlled the MOF surface via an intrinsic reaction between the active site and recombinant proteins to develop a targeted drug delivery platform. This study provides an insight into the potential applications of Zr-MOFs in nanomedicine and the future of the biointerface of MOFs.