There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 3795 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | 3785 | - |
dc.citation.title | JOURNAL OF CELL SCIENCE | - |
dc.citation.volume | 117 | - |
dc.contributor.author | Choi, Jang Hyun | - |
dc.contributor.author | Park, JB | - |
dc.contributor.author | Bae, SS | - |
dc.contributor.author | Yun, S | - |
dc.contributor.author | Kim, HS | - |
dc.contributor.author | Hong, WP | - |
dc.contributor.author | Kim, IS | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Han, MY | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Patterson, RL | - |
dc.contributor.author | Snyder, SH | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.date.accessioned | 2023-12-22T10:44:28Z | - |
dc.date.available | 2023-12-22T10:44:28Z | - |
dc.date.created | 2014-10-14 | - |
dc.date.issued | 2004-08 | - |
dc.description.abstract | Phospholipase C-gamma1 (PLC-gamma1), which interacts with a variety of signaling molecules through its two Src homology (SH) 2 domains and a single SH3 domain has been implicated in the regulation of many cellular functions. We demonstrate that PLC-gamma1 acts as a guanine nucleotide exchange factor (GEF) of dynamin-1, a 100 kDa GTPase protein, which is involved in clathrin-mediated endocytosis of epidermal growth factor (EGF) receptor. Overexpression of PLC-gamma1 increases endocytosis of the EGF receptor by increasing guanine nucleotide exchange activity of dynamin-1. The GEF activity of PLC-gamma1 is mediated by the direct interaction of its SH3 domain with dynamin-1. EGF-dependent activation of ERK and serum response element (SRE) are both up-regulated in PC12 cells stably overexpressing PLC-gamma1, but knockdown of PLC-gamma1 by siRNA significantly reduces ERK activation. These results establish a new role for PLC-gamma1 in the regulation of endocytosis and suggest that endocytosis of activated EGF receptors may mediate PLC-gamma1-dependent proliferation. | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELL SCIENCE, v.117, no.17, pp.3785 - 3795 | - |
dc.identifier.doi | 10.1242/jcs.01220 | - |
dc.identifier.issn | 0021-9533 | - |
dc.identifier.scopusid | 2-s2.0-4444234130 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/7279 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=4444234130 | - |
dc.identifier.wosid | 000223733100009 | - |
dc.language | 영어 | - |
dc.publisher | COMPANY OF BIOLOGISTS LTD | - |
dc.title | Phospholipase C-gamma 1 is a guanine nucleotide exchange factor for dynamin-1 and enhances dynamin-1-dependent epidermal growth factor receptor endocytosis | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.