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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 24727 | - |
dc.citation.number | 34 | - |
dc.citation.startPage | 24721 | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 281 | - |
dc.contributor.author | Kang, Byoung Heon | - |
dc.contributor.author | Altieri, Dario C. | - |
dc.date.accessioned | 2023-12-22T09:43:56Z | - |
dc.date.available | 2023-12-22T09:43:56Z | - |
dc.date.created | 2014-10-10 | - |
dc.date.issued | 2006-08 | - |
dc.description.abstract | Survivin is a multifunctional member of the IAP (inhibitor of apoptosis) family, but its molecular interactions in protection from cell death and regulation of cell division have not been completely elucidated. In a proteomics screening to identify novel survivin-binding partners, we found that the aryl hydrocarbon receptor-interacting protein (AIP) directly associates with survivin in vitro and in co-immunoprecipitation experiments in vivo. This interaction is mediated by the carboxyl-terminal end of AIP, which contains three tetratricopeptide motifs, and involves the carboxyl terminus coiled coil in survivin with critical roles of Asp142 in AIP recognition. A survivin mutant lacking only Asp142 fails to bind AIP and exhibits accelerated degradation in vivo in a reaction reversed by a proteasome inhibitor. Acute knock-down of AIP by short interference RNA or competition of the survivin-AIP complex by peptidyl mimicry destabilizes survivin levels in cells, with enhanced apoptosis but no changes in cell cycle progression. Therefore, AIP regulates survivin stability, thus elevating a cellular anti-apoptotic threshold. The survivin-AIP complex may influence the cellular xenobiotic response to environmental toxin(s) and contribute to subcellular chaperone trafficking during cell death regulation. | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.281, no.34, pp.24721 - 24727 | - |
dc.identifier.doi | 10.1074/jbc.M603175200 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.scopusid | 2-s2.0-33747677470 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/7112 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33747677470 | - |
dc.identifier.wosid | 000239847800068 | - |
dc.language | 영어 | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.title | Regulation of survivin stability by the aryl hydrocarbon receptor-interacting protein | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | CORE COMPLEX | - |
dc.subject.keywordPlus | AH RECEPTOR | - |
dc.subject.keywordPlus | CELL-CYCLE | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | LOCALIZATION | - |
dc.subject.keywordPlus | CHECKPOINT | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | HSP90 | - |
dc.subject.keywordPlus | XAP2 | - |
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