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DC Field | Value | Language |
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dc.citation.endPage | 1340 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1327 | - |
dc.citation.title | INTERNATIONAL IMMUNOLOGY | - |
dc.citation.volume | 15 | - |
dc.contributor.author | Do, Yoonkyung | - |
dc.contributor.author | Rafi-Janajreh, AQ | - |
dc.contributor.author | Mckallip, RJ | - |
dc.contributor.author | Nagarkatti, PS | - |
dc.contributor.author | Nagarkatti, M | - |
dc.date.accessioned | 2023-12-22T11:08:33Z | - |
dc.date.available | 2023-12-22T11:08:33Z | - |
dc.date.created | 2014-10-08 | - |
dc.date.issued | 2003-11 | - |
dc.description.abstract | Patients with mutations in Fas develop autoimmune lymphoproliferative disease (ALPS), While their family members with similar mutations are often normal, thereby suggesting that additional factors may play a role in the development of ALPS. In the current study, we tested the role of CD44 in the development of lymphoproliferative disease by generating CD44 -/-/Fas -/-mice, which failed to express CD44 and Fas, and compared them to CD44 +/+/Fas -/- mice that expressed CD44, but not Fas. The results showed that CD44 -/-/Fas -/- mice developed a more severe lymphoproliferative and autoimmune disease when compared to CD44 +/+/Fas -/- mice. This was indicated by increased numbers of cells in their lymph nodes, and a greater proportion of B220 +CD4 -CD8 - (double-negative) T cells as well as antibodies against single-stranded DNA and chromatin. The heightened severity of lymphoproliferative disease seen in CD44 -/-/Fas -/- mice correlated with increased resistance of T cells, but not B cells, to undergo activation-induced cell death (AICD). The current study suggests that deficiency in CD44 in combination with a defect in one of the molecules involved in the death receptor family such as Fas can further down-regulate AICD, and exacerbate the lymphoproliferative and autoimmune disease. | - |
dc.identifier.bibliographicCitation | INTERNATIONAL IMMUNOLOGY, v.15, no.11, pp.1327 - 1340 | - |
dc.identifier.doi | 10.1093/intimm/dxg132 | - |
dc.identifier.issn | 0953-8178 | - |
dc.identifier.scopusid | 2-s2.0-0242551621 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/7067 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0242551621 | - |
dc.identifier.wosid | 000186325600007 | - |
dc.language | 영어 | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | Combined deficiency in CD44 and Fas leads to exacerbation of lymphoproliferative and autoimmune disease | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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