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Author

Bae, Sung Chul
Multiscale Optical Imaging Lab
Research Interests
  • Multiscale optical imaging, laser spectroscopy, laser microscopy, laser sensing, soft matter physics, surface and interfacial science, laser Matter Interaction

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Nanoparticle-assisted surface immobilization of phospholipid liposomes

Cited 35 times inthomson ciCited 31 times inthomson ci
Title
Nanoparticle-assisted surface immobilization of phospholipid liposomes
Author
Zhang, LiangfangHong, LiangYu, YanBae, Sung ChulGranick, Steve
Keywords
VESICLES; ADSORPTION; MOLECULE; BILAYERS
Issue Date
200607
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.128, no.28, pp.9026 - 9027
Abstract
Phospholipid liposomes (100-200 nm diameter) are deposited onto solid substrates after stabilizing them against fusion with the solid by allowing charged nanoparticles to adsorb at 25% surface coverage. The immobilized vesicles remain stable over a period of days. Epifluorescence imaging shows that they diffuse freely over surfaces with the same charge but adsorb tightly onto surfaces with opposite charge. Nanoparticle adsorption to surface patterns of opposite charge provides a facile method to create large-scale surface-supported arrays of intact liposomes. This surface attachment method is simple chemically and applies generally for solid surfaces that can be hydrophobic or hydrophilic. Offering routes to localize proteins and other vesicle-contained objects at surfaces in tailored spatial patterns, these immobilized liposome arrays may find diverse applications in the emerging field of nanobiotechnology.
URI
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DOI
http://dx.doi.org/10.1021/ja062620r
ISSN
0002-7863
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