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Author

Bae, Sung Chul
Multiscale Optical Imaging Lab
Research Interests
  • Multiscale optical imaging, laser spectroscopy, laser microscopy, laser sensing, soft matter physics, surface and interfacial science, laser Matter Interaction

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Ligand-receptor binding on nanoparticle-stabilized liposome surfaces

Cited 12 times inthomson ciCited 12 times inthomson ci
Title
Ligand-receptor binding on nanoparticle-stabilized liposome surfaces
Author
Zhang, LiangfangDammann, KevinBae, Sung ChulGranick, Steve
Keywords
PHOSPHOLIPID LIPOSOMES; BLOOD CLEARANCE; DRUG-DELIVERY
Issue Date
2007
Publisher
ROYAL SOC CHEMISTRY
Citation
SOFT MATTER, v.3, no.5, pp.551 - 553
Abstract
We explore the access of receptor (streptavidin) to liposome-immobilized ligand (biotin) in cases where the liposomes are stabilized against fusion by allowing nanoparticles to adsorb. It is found that receptor binding persists over that range of nanoparticle surface coverage where liposome fusion and large-scale aggregation are prevented. This indicates that liposome outer surfaces, in the presence of stabilizers, remain biofunctionalizable, and may have bearing on explaining the long circulation time of stabilized liposomes as drug delivery vehicles.
URI
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DOI
http://dx.doi.org/10.1039/b618172d
ISSN
1744-683X
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