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Bae, Sung Chul
Multiscale Optical Imaging Lab
Research Interests
  • Multiscale optical imaging, laser spectroscopy, laser microscopy, laser sensing, soft matter physics, surface and interfacial science, laser Matter Interaction

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Cationic nanoparticles stabilize zwitterionic liposomes better than anionic ones

Cited 21 times inthomson ciCited 20 times inthomson ci
Title
Cationic nanoparticles stabilize zwitterionic liposomes better than anionic ones
Author
Yu, YanAnthony, Stephen M.Zhang, LiangfangBae, Sung ChulGranick, Steve
Keywords
Single-particle tracking; Zwitterionic headgroup
Issue Date
200706
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF PHYSICAL CHEMISTRY C, v.111, no.23, pp.8233 - 8236
Abstract
Building upon the finding that zwitterionic liposomes can be stabilized against fusion up to very high surface coverage by the adsorption to submonolayer (≈25%) surface coverage of nanoparticles (Zhang, L.; Granick, S. Nano Lett. 2006, 6, 694), here we compare the efficacy of cationic and anionic nanoparticles for the stabilization of DLPC, 1,2-dilauroyl-sn-glycero-3- phosphocholine. This is rationalized by considering that because the phospholipid zwitterionic headgroup terminates with positive charge, lipids beneath an adsorbed nanoparticle bind more weakly when the nanoparticle charge is cationic. Going beyond the earlier qualitative study, here single-particle tracking using epi-fluorescence imaging is used to quantify the mobility of individual liposomes. The distribution of diffusion coefficients between different liposomes in the sample is quantified. In contrast to the colloid behavior of traditional monodisperse hard-sphere colloids, these soft, flexible, colloidalsized objects remain fluid at 50% volume fraction of liposomes.
URI
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DOI
http://dx.doi.org/10.1021/jp072680z
ISSN
1932-7447
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