BROWSE

Related Researcher

Author

Lim, Mi Hee
MetalloNeuroChemistry Lab (MNCL)
Research Interests
  • Neurodegenerative disease, small molecule design, network between metal, proteins, and ROS

ITEM VIEW & DOWNLOAD

Cholesterol and metal ions in Alzheimer's disease

Cited 2 times inthomson ciCited 0 times inthomson ci
Title
Cholesterol and metal ions in Alzheimer's disease
Author
Lee, Hyuck JinKorshavn, Kyle J.Kochi, AkikoDerrick, Jeffrey S.Lim, Mi Hee
Keywords
AMYLOID-BETA; OXIDATIVE STRESS; NERVOUS-SYSTEM; EGG-YOLK; COPPER; NEURODEGENERATION; ZINC; METABOLISM; BRAIN; CELLS
Issue Date
201410
Publisher
ROYAL SOC CHEMISTRY
Citation
CHEMICAL SOCIETY REVIEWS, v.43, no.19, pp.6672 - 6682
Abstract
Cholesterol and metal ions have been suggested to be associated with the onset and progression of Alzheimer's disease (AD). Moreover, recent findings have demonstrated a potential interconnection between these two factors. For example, (a) cholesterol has been shown to be misregulated in AD-afflicted brains, and the aberrant activity of proteins (particularly, apolipoprotein E (ApoE) and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)) has been linked to cholesterol-related AD exacerbation; (b) dyshomeostasis of metal ions associated with misfolded proteins (i.e., amyloid-β (Aβ) aggregates) found in the brains of AD patients is shown to promote oxidative stress leading to the malfunction of multiple proteins, including cytochrome c oxidase (CcO), and Cu/Zn superoxide dismutase (SOD1); (c) metal ion misregulation has also been observed to disrupt the activity of proteins (e.g., HMGR, low-density lipoproteins (LDL)), required for cholesterol production and regulation. Herein, we briefly discuss the potential involvement of cholesterol and metal ions in AD neuropathogenesis in both individual and interrelated manners.
URI
Go to Link
DOI
http://dx.doi.org/10.1039/c4cs00005f
ISSN
0306-0012
Appears in Collections:
SNS_Journal Papers

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qr_code

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU