Full metadata record
DC Field | Value | Language |
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dc.citation.number | 11 | - |
dc.citation.startPage | e977 | - |
dc.citation.title | HEMASPHERE | - |
dc.citation.volume | 7 | - |
dc.contributor.author | Jang, Jinho | - |
dc.contributor.author | Kim, Hongtae | - |
dc.contributor.author | Park, Sung-Soo | - |
dc.contributor.author | Kim, Miok | - |
dc.contributor.author | Min, Yong Ki | - |
dc.contributor.author | Jeong, Hyoung-oh | - |
dc.contributor.author | Kim, Seunghoon | - |
dc.contributor.author | Hwang, Taejoo | - |
dc.contributor.author | Choi, David Whee-Young | - |
dc.contributor.author | Kim, Hee-Je | - |
dc.contributor.author | Song, Sukgil | - |
dc.contributor.author | Kim, Dong Oh | - |
dc.contributor.author | Lee, Semin | - |
dc.contributor.author | Lee, Chang Hoon | - |
dc.contributor.author | Lee, Jong Wook | - |
dc.date.accessioned | 2023-12-21T11:41:19Z | - |
dc.date.available | 2023-12-21T11:41:19Z | - |
dc.date.created | 2023-11-21 | - |
dc.date.issued | 2023-11 | - |
dc.description.abstract | Aplastic anemia (AA) is a lethal hematological disorder; however, its pathogenesis is not fully understood. Although immunosuppressive therapy (IST) is a major treatment option for AA, one-third of patients do not respond to IST and its resistance mechanism remains elusive. To understand AA pathogenesis and IST resistance, we performed single-cell RNA sequencing (scRNA-seq) of bone marrow (BM) from healthy controls and patients with AA at diagnosis. We found that CD34(+) early-stage erythroid precursor cells and PROM1(+) hematopoietic stem cells were significantly depleted in AA, which suggests that the depletion of CD34(+) early-stage erythroid precursor cells and PROM1(+) hematopoietic stem cells might be one of the major mechanisms for AA pathogenesis related with BM-cell hypoplasia. More importantly, we observed the significant enrichment of CD8(+) T cells and T cell-activating intercellular interactions in IST responders, indicating the association between the expansion and activation of T cells and the positive response of IST in AA. Taken together, our findings represent a valuable resource offering novel insights into the cellular heterogeneity in the BM of AA and reveal potential biomarkers for IST, building the foundation for future precision therapies in AA. | - |
dc.identifier.bibliographicCitation | HEMASPHERE, v.7, no.11, pp.e977 | - |
dc.identifier.doi | 10.1097/HS9.0000000000000977 | - |
dc.identifier.issn | 2572-9241 | - |
dc.identifier.scopusid | 2-s2.0-85175614829 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/66234 | - |
dc.identifier.wosid | 001088394400001 | - |
dc.language | 영어 | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | Single-cell RNA Sequencing Reveals Novel Cellular Factors for Response to Immunosuppressive Therapy in Aplastic Anemia | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalResearchArea | Hematology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | HEMATOPOIETIC STEM | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | COSTIMULATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | ELTROMBOPAG | - |
dc.subject.keywordPlus | AUTOIMMUNE | - |
dc.subject.keywordPlus | PROGENITOR | - |
dc.subject.keywordPlus | ENGAGEMENT | - |
dc.subject.keywordPlus | MOLECULE | - |
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