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DC Field | Value | Language |
---|---|---|
dc.citation.startPage | 144357 | - |
dc.citation.title | CHEMICAL ENGINEERING JOURNAL | - |
dc.citation.volume | 470 | - |
dc.contributor.author | Oh, Jun Yong | - |
dc.contributor.author | An, Eun-Koung | - |
dc.contributor.author | Jana, Batakrishna | - |
dc.contributor.author | Kim, Hansol | - |
dc.contributor.author | Jin, Seongeon | - |
dc.contributor.author | Yang, Gyeongseok | - |
dc.contributor.author | Kim, Jinsoo | - |
dc.contributor.author | Choi, Eunshil | - |
dc.contributor.author | Jin, Jun-O | - |
dc.contributor.author | Ryu, Ja-Hyoung | - |
dc.date.accessioned | 2023-12-21T11:48:29Z | - |
dc.date.available | 2023-12-21T11:48:29Z | - |
dc.date.created | 2023-08-02 | - |
dc.date.issued | 2023-08 | - |
dc.description.abstract | For effective drug delivery using nanoparticles, antibody can be beneficially utilized thanks to its high binding affinity to the target site. However, a conventional method to conjugate antibody to nanoparticles involves a multi-step synthetic process, which can damage the antibody's intrinsic target-recognition nature. Herein, a facile approach is reported to construct a versatile targeted delivery platform, to which any desired antibodies are allowed to directly bind, by coating the nanoparticle surface with a functional fusion protein consisting of glutathione-S-transferase (GST) and the antibody-binding domain (ABD) called Z domain. The antibody-plugged nanoparticle exhibits high structural stability in biological environments and cell-specific targeting behaviors, significantly enhancing drug delivery efficiency both in vitro and in vivo for diverse therapeutic applications. | - |
dc.identifier.bibliographicCitation | CHEMICAL ENGINEERING JOURNAL, v.470, pp.144357 | - |
dc.identifier.doi | 10.1016/j.cej.2023.144357 | - |
dc.identifier.issn | 1385-8947 | - |
dc.identifier.scopusid | 2-s2.0-85163170306 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/65163 | - |
dc.identifier.wosid | 001024325200001 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER SCIENCE SA | - |
dc.title | Antibody plug-and-playable nanoparticles as a facile and versatile platform for targeted drug delivery | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Engineering, Environmental; Engineering, Chemical | - |
dc.relation.journalResearchArea | Engineering | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Antibody | - |
dc.subject.keywordAuthor | Z domain | - |
dc.subject.keywordAuthor | GST-ABD | - |
dc.subject.keywordAuthor | Targeting | - |
dc.subject.keywordAuthor | Mesoporous silica | - |
dc.subject.keywordAuthor | Drug delivery | - |
dc.subject.keywordPlus | MESOPOROUS SILICA NANOPARTICLES | - |
dc.subject.keywordPlus | NANOCARRIERS | - |
dc.subject.keywordPlus | IMMOBILIZATION | - |
dc.subject.keywordPlus | FRAGMENT | - |
dc.subject.keywordPlus | DOMAIN | - |
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