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Song, Hyun-Kon
eclat: ElectroChemistry Lab of Advanced Technology
Research Interests
  • Electrochemical analysis, electroactive materials, electrochemistry-based energy devices

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Combined topographical and chemical micropatterns for templating neuronal networks

Cited 31 times inthomson ciCited 31 times inthomson ci
Title
Combined topographical and chemical micropatterns for templating neuronal networks
Author
Venkataramani, SowmyaXu, HengSong, Yoon-KyuSong, Hyun-KonPalmore, G. Tayhas R.Fallon, JustinNurmikko, Arto V.
Keywords
Bioelectronic interface; Cell culture; Micropatterning; Neural network; Photolithography
Issue Date
200611
Publisher
ELSEVIER SCI LTD
Citation
BIOMATERIALS, v.27, no.33, pp.5734 - 5739
Abstract
In vitro neuronal networks with geometrically defined features are desirable for studying long-term electrical activity within the neuron assembly and for interfacing with external microelectronic circuits. In standard cultures, the random spatial distribution and overlap of neurites makes this aim difficult; hence, many recent efforts have been made on creating patterned cellular circuits. Here, we present a novel method for creating a planar neural network that is compatible with optical devices. This method combines both topographical and chemical micropatterns onto which neurons can be cultured. Compared to other reported patterning techniques, our approach and choice of template appears to show both geometrical control over the formation of specific neurite connections at low plating density and compatibility with microelectronic circuits that stimulate and record neural activity.
URI
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DOI
http://dx.doi.org/10.1016/j.biomaterials.2006.07.021
ISSN
0142-9612
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