Full metadata record
DC Field | Value | Language |
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dc.citation.endPage | 180 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 163 | - |
dc.citation.title | KIDNEY INTERNATIONAL | - |
dc.citation.volume | 104 | - |
dc.contributor.author | Yoo, Eun Jin | - |
dc.contributor.author | Oh, Kook-Hwan | - |
dc.contributor.author | Piao, Honglin | - |
dc.contributor.author | Kang, Hyun Je | - |
dc.contributor.author | Jeong, Gyu Won | - |
dc.contributor.author | Park, Hyun | - |
dc.contributor.author | Lee, Chang Jun | - |
dc.contributor.author | Ryu, Hyunjin | - |
dc.contributor.author | Yang, Seung Hee | - |
dc.contributor.author | Kim, Myung-Gyu | - |
dc.contributor.author | Kim, Dong Ki | - |
dc.contributor.author | Park, Sung Ho | - |
dc.contributor.author | Lim, Beom Jin | - |
dc.contributor.author | Lee, Sang Min | - |
dc.contributor.author | Park, Chan Young | - |
dc.contributor.author | Choi, Soo Youn | - |
dc.contributor.author | Lee-Kwon, Whaseon | - |
dc.contributor.author | Yang, Jaeseok | - |
dc.contributor.author | Kwon, Hyug Moo | - |
dc.date.accessioned | 2023-12-21T11:53:29Z | - |
dc.date.available | 2023-12-21T11:53:29Z | - |
dc.date.created | 2023-07-10 | - |
dc.date.issued | 2023-07 | - |
dc.description.abstract | Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by autoreactive B cells and dysregulation of many other types of immune cells including myeloid cells. Lupus nephritis (LN) is a common target organ manifestations of SLE. Tonicity-responsive enhancer-binding protein (TonEBP, also known as nuclear factor of activated T-cells 5 (NFAT5)), was initially identified as a central regulator of cellular responses to hypertonic stress and is a pleiotropic stress protein involved in a variety of immunometabolic diseases. To explore the role of TonEBP, we examined kidney biopsy samples from patients with LN. Kidney TonEBP expression was found to be elevated in these patients compared to control patients – in both kidney cells and infiltrating immune cells. Kidney TonEBP mRNA was elevated in LN and correlated with mRNAs encoding inflammatory cytokines and the degree of proteinuria. In a pristane-induced SLE model in mice, myeloid TonEBP deficiency blocked the development of SLE and LN. In macrophages, engagement of various toll-like receptors (TLRs) that respond to damage-associated molecular patterns induced TonEBP expression via stimulation of its promoter. Intracellular signaling downstream of the TLRs was dependent on TonEBP. Therefore, TonEBP can act as a transcriptional cofactor for NF-κB, and activated mTOR-IRF3/7 via protein-protein interactions. Additionally, TonEBP-deficient macrophages displayed elevated efferocytosis and animals with myeloid deficiency of TonEBP showed reduced Th1 and Th17 differentiation, consistent with macrophages defective in TLR signaling. Thus, our data show that myeloid TonEBP may be an attractive therapeutic target for SLE and LN. | - |
dc.identifier.bibliographicCitation | KIDNEY INTERNATIONAL, v.104, no.1, pp.163 - 180 | - |
dc.identifier.doi | 10.1016/j.kint.2023.03.030 | - |
dc.identifier.issn | 0085-2538 | - |
dc.identifier.scopusid | 2-s2.0-85156262118 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/64771 | - |
dc.identifier.wosid | 001034207800001 | - |
dc.language | 영어 | - |
dc.publisher | Elsevier Inc. | - |
dc.title | Macrophage transcription factor TonEBP promotes systemic lupus erythematosus and kidney injury via damage-induced signaling pathways | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | glomerulonephritis | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | lupus | - |
dc.subject.keywordAuthor | macrophages | - |
dc.subject.keywordAuthor | systemic lupus erythematosus | - |
dc.subject.keywordPlus | APOPTOTIC CELLS | - |
dc.subject.keywordPlus | CLEARANCE | - |
dc.subject.keywordPlus | POLYMORPHISMS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | INTERFERON REGULATORY FACTOR-3 | - |
dc.subject.keywordPlus | PLASMACYTOID DENDRITIC CELLS | - |
dc.subject.keywordPlus | ENHANCER-BINDING PROTEIN | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTORS | - |
dc.subject.keywordPlus | GENETIC-VARIATION | - |
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