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Author

Kang, Sebyung
Protein Nanobio Lab
Research Interests
  • Protein engineering, Drug/diagnostics delivery nanoplatform, Protein-base vaccine delivery systems, Biosensor & imaging

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Janus-like Protein Cages. Spatially Controlled Dual-Functional Surface Modifications of Protein Cages

Cited 24 times inthomson ciCited 23 times inthomson ci
Title
Janus-like Protein Cages. Spatially Controlled Dual-Functional Surface Modifications of Protein Cages
Author
Kang, SebyungSuci, Peter A.Broomell, Chris C.Iwahori, KenjiKobayashi, MimeYamashita, IchiroYoung, MarkDouglas, Trevor
Keywords
Directed assembly; Functional surfaces; Functionalized; Hierarchical assemblies; Higher order; Layer-by-layer assemblies; Nano-materials; Nanoscale building blocks; Protein cages; Reaction vessel; Spatial distribution
Issue Date
200906
Publisher
AMER CHEMICAL SOC
Citation
NANO LETTERS, v.9, no.6, pp.2360 - 2366
Abstract
Protein cages have been used both as size-constrained reaction vessels for nanomaterials synthesis and as nanoscale building blocks for higher order nanostructures. We generated Janus-like protein cages, which are dual functionalized with a fluorescent and an affinity label, and demonstrated control over both the stoichiometry and spatial distribution of the functional groups. The capability to toposelectively functionalize protein cages has allowed us to manipulate hierarchical assembly using the layer-by-layer assembly process. Janus-like protein cages expand the toolkit of nanoplatforms that can be used for directed assembly of nanostructured materials.
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DOI
http://dx.doi.org/10.1021/nl9009028
ISSN
1530-6984
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