Continuous monitoring of protein damaging toxicity using a recombinant bioluminescent Escherichia coli
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- Continuous monitoring of protein damaging toxicity using a recombinant bioluminescent Escherichia coli
- Gu, M.B.; Mitchell, Robert J.; Kim, J.H.
- Issue Date
- American Chemical Society
- ACS SYMPOSIUM SERIES, v.762, no., pp.185 - 196
- Through the use of the recombinant bacterium TV 1061, containing a grpE-luxCDABE fusion, and a previously developed continuous toxicity monitoring system we were able to detect protein damaging toxicity in aqueous systems. This bacterial strain is responsive to the toxicity of protein-damaging agents and produces a bioluminescent response in their presence. The system uses the two-stage mini-bioreactors previously developed in our lab which allows stability even under the conditions that the toxicity greatly exceeded the sub-lethal level. The response of the strain under these conditions shows a unique signature when compared to previously tested strains.
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