BROWSE

Related Researcher

Author

Cho, Moo Je
Ulsan National Institute of Science and Technology
Research Interests
  • Calcium Signaling

ITEM VIEW & DOWNLOAD

Calmodulin interacts with MLO protein to regulate defence against mildew in barley

Cited 170 times inthomson ciCited 174 times inthomson ci
Title
Calmodulin interacts with MLO protein to regulate defence against mildew in barley
Author
Kim, MCPanstruga, RElliott, CMuller, JDevoto, AYoon, HWPark, HCCho, Moo JeSchulze-Lefert, P
Keywords
POWDERY MILDEW; ALPHA-SUBUNIT; CELL-DEATH; DISEASE RESISTANCE; OXIDATIVE BURST; ACTIVATION; CALCIUM; MUTATIONS; GENE; INCREASE
Issue Date
200203
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE, v.416, no.6879, pp.447 - 450
Abstract
In plants, defence against specific isolates of a pathogen can be triggered by the presence of a corresponding race-specific resistance gene, whereas resistance of a more broad-spectrum nature can result from recessive, presumably loss-of-regulatory-function, mutations. An example of the latter are mlo mutations in barley, which have been successful in agriculture for the control of powdery mildew fungus (Blumeria graminis f. sp. hordei; Bgh). MLO protein resides in the plasma membrane, has seven transmembrane domains, and is the prototype of a sequence-diversified family unique to plants, reminiscent of the seven-transmembrane receptors in fungi and animals. In animals, these are known as G-protein- coupled receptors and exist in three main families, lacking sequence similarity, that are thought to be an example of molecular convergence. MLO seems to function independently of heterotrimeric G proteins. We have identified a domain in MLO that mediates a Ca2+-dependent interaction with calmodulin in vitro. Loss of calmodulin binding halves the ability of MLO to negatively regulate defence against powdery mildew in vivo. We propose a sensor role for MLO in the modulation of defence reactions.
URI
Go to Link
DOI
http://dx.doi.org/10.1038/416447a
ISSN
0028-0836
Appears in Collections:
SLS_Journal Papers

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qr_code

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU