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Cho, Moo Je
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Calmodulin interacts with MLO protein to regulate defence against mildew in barley

Author(s)
Kim, MCPanstruga, RElliott, CMuller, JDevoto, AYoon, HWPark, HCCho, Moo JeSchulze-Lefert, P
Issued Date
2002-03
DOI
10.1038/416447a
URI
https://scholarworks.unist.ac.kr/handle/201301/6286
Fulltext
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037187626
Citation
NATURE, v.416, no.6879, pp.447 - 450
Abstract
In plants, defence against specific isolates of a pathogen can be triggered by the presence of a corresponding race-specific resistance gene, whereas resistance of a more broad-spectrum nature can result from recessive, presumably loss-of-regulatory-function, mutations. An example of the latter are mlo mutations in barley, which have been successful in agriculture for the control of powdery mildew fungus (Blumeria graminis f. sp. hordei; Bgh). MLO protein resides in the plasma membrane, has seven transmembrane domains, and is the prototype of a sequence-diversified family unique to plants, reminiscent of the seven-transmembrane receptors in fungi and animals. In animals, these are known as G-protein- coupled receptors and exist in three main families, lacking sequence similarity, that are thought to be an example of molecular convergence. MLO seems to function independently of heterotrimeric G proteins. We have identified a domain in MLO that mediates a Ca2+-dependent interaction with calmodulin in vitro. Loss of calmodulin binding halves the ability of MLO to negatively regulate defence against powdery mildew in vivo. We propose a sensor role for MLO in the modulation of defence reactions.
Publisher
NATURE PUBLISHING GROUP
ISSN
0028-0836

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