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Cho, Moo Je
Ulsan National Institute of Science and Technology
Research Interests
  • Calcium Signaling

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BWMK1, a rice mitogen-activated protein kinase, locates in the nucleus and mediates pathogenesis-related gene expression by activation of a transcription factor

Cited 137 times inthomson ciCited 154 times inthomson ci
Title
BWMK1, a rice mitogen-activated protein kinase, locates in the nucleus and mediates pathogenesis-related gene expression by activation of a transcription factor
Author
Cheong, YHMoon, BCKim, JKKim, CYKim, MCKim, IHPark, Chan YoungKim, JCPark, BOKoo, SCYoon, HWChung, WSLim, COLee, SYCho, Moo Je
Keywords
ETHYLENE-RESPONSIVE ELEMENT; SYSTEMIC ACQUIRED-RESISTANCE; DNA-BINDING PROTEIN; MAP KINASE; SALICYLIC-ACID; DISEASE RESISTANCE; SIGNAL-TRANSDUCTION; ARABIDOPSIS-THALIANA; DEFENSE RESPONSES; HIGHER-PLANTS
Issue Date
200308
Publisher
AMER SOC PLANT BIOLOGISTS
Citation
PLANT PHYSIOLOGY, v.132, no.4, pp.1961 - 1972
Abstract
Mitogen-activated protein kinase (MAPK) cascades are known to transduce plant defense signals, but the downstream components of the MAPK have as yet not been elucidated. Here, we report an MAPK from rice (Oryza sativa), BWMK1, and a transcription factor, OsEREBP1, phosphorylated by the kinase. The MAPK carries a TDY phosphorylation motif instead of the more common TEY motif in its kinase domain and has an unusually extended C-terminal domain that is essential to its kinase activity and translocation to the nucleus. The MAPK phosphorylates OsEREBP1 that binds to the GCC box element (AGCCGCC) of the several basic pathogenesis-related gene promoters, which in turn enhances DNA-binding activity of the factor to the cis element in vitro. Transient co-expression of the BWMK1 and OsEREBP1 in Arabidopsis protoplasts elevates the expression of the beta-glucuronidase reporter gene driven by the GCC box element. Furthermore, transgenic tobacco (Nicotiana tabacum) plants overexpressing BWMK1 expressed many pathogenesis-related genes at higher levels than wild-type plants with an enhanced resistance to pathogens. These findings suggest that MAPKs contribute to plant defense signal transduction by phosphorylating one or more transcription factors.
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DOI
http://dx.doi.org/10.1104/pp.103.023176
ISSN
0032-0889
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