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GrzybowskiBartosz Andrzej

Grzybowski, Bartosz A.
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dc.citation.endPage 58 -
dc.citation.number 1 -
dc.citation.startPage 49 -
dc.citation.title NATURE SYNTHESIS -
dc.citation.volume 1 -
dc.contributor.author Molga, Karol -
dc.contributor.author Szymkuć, Sara -
dc.contributor.author Gołębiowska, Patrycja -
dc.contributor.author Popik, Oskar -
dc.contributor.author Dittwald, Piotr -
dc.contributor.author Moskal, Martyna -
dc.contributor.author Roszak, Rafal -
dc.contributor.author Mlynarski, Jacek -
dc.contributor.author Grzybowski, Bartosz A. -
dc.date.accessioned 2023-12-21T14:42:07Z -
dc.date.available 2023-12-21T14:42:07Z -
dc.date.created 2022-01-25 -
dc.date.issued 2022-01 -
dc.description.abstract Iterative syntheses comprise sequences of organic reactions in which the substrate molecules grow with each iteration and the functional groups, which enable the growth step, are regenerated to allow sustained cycling. Typically, iterative sequences can be automated, for example, as in the transformative examples of the robotized syntheses of peptides, oligonucleotides, polysaccharides and even some natural products. However, iterations are not easy to identify—in particular, for sequences with cycles more complex than protection and deprotection steps. Indeed, the number of catalogued examples is in the tens to maybe a hundred. Here, a computer algorithm using a comprehensive knowledge base of individual reactions constructs and evaluates myriads of putative, but chemically plausible, sequences and discovers an unprecedented number of iterative sequences. Some of these iterations are validated by experiment and result in the synthesis of motifs commonly found in natural products. This computer-driven discovery expands the pool of iterative sequences that may be automated in the future. -
dc.identifier.bibliographicCitation NATURE SYNTHESIS, v.1, no.1, pp.49 - 58 -
dc.identifier.doi 10.1038/s44160-021-00010-3 -
dc.identifier.issn 2731-0582 -
dc.identifier.scopusid 2-s2.0-85128852099 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/61160 -
dc.language 영어 -
dc.publisher Springer Science and Business Media LLC -
dc.title A computer algorithm to discover iterative sequences of organic reactions -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.type.docType Article -
dc.description.journalRegisteredClass scopus -

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