BROWSE

Related Researcher

Author

Min, Kyung-Tai
Molecular & Cellular Neurobiology Lab(Min Lab)
Research Interests
  • Local protein synthesis, learning & memory, behavior, mitochondrial dynamics

ITEM VIEW & DOWNLOAD

SIGMA(F), THE 1ST COMPARTMENT-SPECIFIC TRANSCRIPTION FACTOR OF BACILLUS-SUBTILIS, IS REGULATED BY AN ANTI-SIGMA FACTOR THAT IS ALSO A PROTEIN-KINASE

Cited 211 times inthomson ciCited 177 times inthomson ci
Title
SIGMA(F), THE 1ST COMPARTMENT-SPECIFIC TRANSCRIPTION FACTOR OF BACILLUS-SUBTILIS, IS REGULATED BY AN ANTI-SIGMA FACTOR THAT IS ALSO A PROTEIN-KINASE
Author
Min, Kyung-TaiHILDITCH, CMDIEDERICH, BERRINGTON, JYUDKIN, MD
Keywords
BACILLUS-SUBTILIS; GENE-EXPRESSION; NUCLEOTIDE-SEQUENCE; RNA-POLYMERASE; LOCUS SPOIIA; CELL-TYPE; SPORULATION; CLONING; DNA; MUTATIONS
Issue Date
199308
Publisher
CELL PRESS
Citation
CELL, v.74, no.4, pp.735 - 742
Abstract
The establishment of compartment-specific transcription in sporulating cells of B. subtilis is governed at the level of the activity of transcription factor sigma(F). Genetic experiments have suggested that SpollAA and SpollAB, the other products of the sigma(F) operon, are involved in regulating sigma(F) activity. This activity is inhibited in the predivisional cell but specifically released from inhibition in the prespore about 1.5 hr after sporulation is induced. We now show that purified SpollAB inhibits transcription directed by sigma(F) in vitro. We note that the amino acid sequence of SpollAB shows some similarity to a group of bacterial histidine protein kinases, and we find that SpollAB is indeed a protein kinase that phosphorylates SpollAA on a serine residue. We suggest that this phosphorylation is responsible for the compartment-specific release of sigma(F) activity, perhaps through the formation of a tight complex between SpollAB and phosphorylated SpollAA.
URI
Go to Link
DOI
http://dx.doi.org/10.1016/0092-8674(93)90520-Z
ISSN
0092-8674
Appears in Collections:
SLS_Journal Papers

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qr_code

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU