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Author

Min, Kyung-Tai
Molecular & Cellular Neurobiology Lab(Min Lab)
Research Interests
  • Local protein synthesis, learning & memory, behavior, mitochondrial dynamics

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Regulation of lifespan by histone deacetylase

Cited 58 times inthomson ciCited 67 times inthomson ci
Title
Regulation of lifespan by histone deacetylase
Author
Chang, KTMin, Kyung-Tai
Keywords
Aging; Histone deacetylase; Lifespan
Issue Date
200206
Publisher
ELSEVIER IRELAND LTD
Citation
AGEING RESEARCH REVIEWS, v.1, no.3, pp.313 - 326
Abstract
Aging is a universal biological phenomenon in eukaryotes, but why and how we age still remain mysterious. It would be of great biological interest and practical importance if we could uncover the molecular mechanism of aging, and find a way to delay the aging process while maintaining physical and mental strengths of youth. Histone deacetylases (HDACs) such as SIR2 and RPD3 are known to be involved in the extension of lifespan in yeast and Caenorhabditis elegans. An inhibitor of HDACs, phenylbutyrate, also can significantly increase the lifespan of Drosophila, without diminution of locomotor vigor, resistance to stress, or reproductive ability. Treatment for a limited period, either early or late in adult life, is also effective. Alteration in the pattern of gene expression, including induction or repression of numerous genes involved in longevity by changing the level and the pattern of histone acetylation may be an important factor in determining the longevity of animals.
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DOI
http://dx.doi.org/10.1016/S1568-1637(02)00003-X
ISSN
1568-1637
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