Full metadata record
DC Field | Value | Language |
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dc.citation.number | 22 | - |
dc.citation.startPage | 4058 | - |
dc.citation.title | NANOMATERIALS | - |
dc.citation.volume | 12 | - |
dc.contributor.author | Zhou, Jie | - |
dc.contributor.author | Chen, Ning | - |
dc.contributor.author | Liao, Jing | - |
dc.contributor.author | Tian, Gan | - |
dc.contributor.author | Mei, Linqiang | - |
dc.contributor.author | Yang, Guoping | - |
dc.contributor.author | Wang, Qiang | - |
dc.contributor.author | Yin, Wenyan | - |
dc.date.accessioned | 2023-12-21T13:18:26Z | - |
dc.date.available | 2023-12-21T13:18:26Z | - |
dc.date.created | 2022-12-23 | - |
dc.date.issued | 2022-11 | - |
dc.description.abstract | Silver nanoparticles (Ag NPs), a commonly used antibacterial nanomaterial, exhibit broad-spectrum antibacterial activity to combat drug-resistant bacteria. However, the Ag NPs often causes a low availability and high toxicity to living bodies due to their easy aggregation and uncontrolled release of Ag+ in the bacterial microenvironment. Here, we report a porous metal-organic framework (MOF)-based Zr-2-amin-1,4-NH2-benzenedicarboxylate@Ag (denoted as UiO-66-NH2-Ag) nanocomposite using an in-situ immobilization strategy where Ag NPs were fixed on the UiO-66-NH2 for improving the dispersion and utilization of Ag NPs. As a result, the reduced use dose of Ag NPs largely improves the biosafety of the UiO-66-NH2-Ag. Meanwhile, after activation by the Ag NPs, the UiO-66-NH2-Ag can act as nanozyme with high peroxidase (POD)-like activity to efficiently catalyze the decomposition of H2O2 to extremely toxic hydroxyl radicals (center dot OH) in the bacterial microenvironment. Simultaneously, the high POD-like activity synergies with the controllable Ag+ release leads to enhanced reactive oxygen species (ROS) generation, facilitating the death of resistant bacteria. This synergistic antibacterial strategy enables the low concentration (12 mu g/mL) of UiO-66-NH2-Ag to achieve highly efficient inactivation of ampicillin-resistant Escherichia coli (Amp(r) E. coli) and endospore-forming Bacillus subtilis (B. subtilis). In vivo results illustrate that the UiO-66-NH2-Ag nanozyme has a safe and accelerated bacteria-infected wound healing. | - |
dc.identifier.bibliographicCitation | NANOMATERIALS, v.12, no.22, pp.4058 | - |
dc.identifier.doi | 10.3390/nano12224058 | - |
dc.identifier.issn | 2079-4991 | - |
dc.identifier.scopusid | 2-s2.0-85142460042 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/60701 | - |
dc.identifier.wosid | 000887848900001 | - |
dc.language | 영어 | - |
dc.publisher | MDPI | - |
dc.title | Ag-Activated Metal-Organic Framework with Peroxidase-like Activity Synergistic Ag+ Release for Safe Bacterial Eradication and Wound Healing | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied | - |
dc.relation.journalResearchArea | Chemistry; Science & Technology - Other Topics; Materials Science; Physics | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | antibacterial | - |
dc.subject.keywordAuthor | silver ions release | - |
dc.subject.keywordAuthor | nanozyme | - |
dc.subject.keywordAuthor | metal-organic framework | - |
dc.subject.keywordAuthor | wound healing | - |
dc.subject.keywordPlus | SILVER NANOPARTICLES | - |
dc.subject.keywordPlus | ANTIBACTERIAL ACTIVITY | - |
dc.subject.keywordPlus | NANOCOMPOSITE | - |
dc.subject.keywordPlus | CONSTRUCTION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | ION | - |
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