Individual histone deacetylases in Drosophila modulate transcription of distinct genes
Cited 36 times inCited 40 times in
- Individual histone deacetylases in Drosophila modulate transcription of distinct genes
- Cho, YS; Griswold, A; Campbell, C; Min, Kyung-Tai
- Aging; Drosophila; HDAC inhibitors; HDACs; Microarray
- Issue Date
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- GENOMICS, v.86, no.5, pp.606 - 617
- Lysine residues on the N-terminal tails of histones in chromatin are the primary targets of histone acetyltransferases (HATs) and histone deacetylases (HDACs) in eukaryotes. Regulation of histone acetylation by these two classes of enzymes plays significant roles in controlling transcriptional activity in cells. Eukaryotic organisms have several different HDACs, but the biological roles of each HDAC are still not clear. To understand the physiological functions of HDACs, we characterized six different Drosophila HDACs, including Rpd3, HDAC3, HDAC4, HDAC6-S, HDAC6-L, and Sir2, by developmental expression pattern, transcriptional profiles of target genes, and sensitivity to HDAC inhibitors. We found that each HDAC has a distinct temporal expression pattern and regulates transcription of a unique set of genes. Furthermore, we demonstrated differential sensitivity of HDACs to inhibitors. These results show that each individual HDAC plays different roles in regulating genes involved in various biological processes.
- ; Go to Link
Appears in Collections:
- SLS_Journal Papers
can give you direct access to the published full text of this article. (UNISTARs only)
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.