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Min, Kyung-Tai
Molecular & Cellular Neurobiology Lab(Min Lab)
Research Interests
  • Local protein synthesis, learning & memory, behavior, mitochondrial dynamics

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Overexpression of frataxin in the mitochondria increases resistance to oxidative stress and extends lifespan in Drosophila

Cited 29 times inthomson ciCited 30 times inthomson ci
Title
Overexpression of frataxin in the mitochondria increases resistance to oxidative stress and extends lifespan in Drosophila
Author
Runkoa, Alexander P.Griswold, Anthony J.Min, Kyung-Tai
Keywords
Drosophila; Frataxin; Friedreich's ataxia; Oxidative stress
Issue Date
200803
Publisher
ELSEVIER SCIENCE BV
Citation
FEBS LETTERS, v.582, no.5, pp.715 - 719
Abstract
In Friedreich's ataxia, reduction of the mitochondria protein frataxin results in the accumulation of iron and reactive oxygen species, which leads to oxidative damage, neurodegeneration and a diminished lifespan. Recent studies propose that frataxin might play a role in the antioxidative process. Here we show that overexpression of Drosophila frataxin in the mitochondria of female transgenic animals increases antioxidant capability, resistance to oxidative stress insults, and longevity. This suggests that Drosophila frataxin may function to protect the mitochondria from oxidative stresses and the ensuing cellular damage. ⓒ 2008 Federation of European Biochemical Societies.
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DOI
http://dx.doi.org/10.1016/j.febslet.2008.01.046
ISSN
0014-5793
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