dc.citation.endPage |
1421 |
- |
dc.citation.number |
12 |
- |
dc.citation.startPage |
1416 |
- |
dc.citation.title |
RSC CHEMICAL BIOLOGY |
- |
dc.citation.volume |
3 |
- |
dc.contributor.author |
Jeena, M.T. |
- |
dc.contributor.author |
Jin, Seongeon |
- |
dc.contributor.author |
Jana, Batakrishna |
- |
dc.contributor.author |
Ryu, Ja-Hyoung |
- |
dc.date.accessioned |
2023-12-21T13:15:55Z |
- |
dc.date.available |
2023-12-21T13:15:55Z |
- |
dc.date.created |
2022-10-18 |
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dc.date.issued |
2022-12 |
- |
dc.description.abstract |
The treatment of osteosarcoma involves an adjuvant therapy that combines surgery and chemotherapy. However, considering that children are the main victims of osteosarcoma, replacing such a harsh treatment with a soft but powerful method that ensures a complete cure while having no adverse effects is highly desirable. To achieve this aim, we have developed a supramolecular therapeutic strategy based on morphology-transformable mitochondria-targeting peptides for the eradication of osteosarcoma with enhanced selectivity and reduced side effects. A newly designed micelle-forming amphiphilic peptide, L-Mito-FFYp, consisting of a phosphate substrate for the biomarker enzyme of osteosarcoma alkaline phosphatase (ALP), disassembles in response to the ALP enzyme in the cell membrane to generate positively charged L-Mito-FFY molecules, which diffuse inside the targeted cell and self-assemble to form nanostructures specifically inside the mitochondria to induce cell apoptosis. |
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dc.identifier.bibliographicCitation |
RSC CHEMICAL BIOLOGY, v.3, no.12, pp.1416 - 1421 |
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dc.identifier.doi |
10.1039/d2cb00166g |
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dc.identifier.issn |
2633-0679 |
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dc.identifier.scopusid |
2-s2.0-85141300007 |
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dc.identifier.uri |
https://scholarworks.unist.ac.kr/handle/201301/59753 |
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dc.language |
영어 |
- |
dc.publisher |
ROYAL SOC CHEMISTRY |
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dc.title |
Enzyme-instructed morphology transformation of mitochondria-targeting peptide for the selective eradication of osteosarcoma |
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dc.type |
Article |
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dc.description.isOpenAccess |
FALSE |
- |
dc.description.journalRegisteredClass |
scopus |
- |