Mitochondrial matrix Ca2+ as an intrinsic signal regulating mitochondrial motility in axons
Cited 21 times inCited 18 times in
- Mitochondrial matrix Ca2+ as an intrinsic signal regulating mitochondrial motility in axons
- Chang, Karen T.; Niescier, Robert F.; Min, Kyung-Tai
- FLUORESCENT PROTEIN; CALCIUM UNIPORTER; GROWTH-FACTOR; TRANSPORT; HOMEOSTASIS; INHIBITOR; MECHANISM; MOVEMENT; SB202190; NEURONS
- Issue Date
- NATL ACAD SCIENCES
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.108, no.37, pp.15456 - 15461
- The proper distribution of mitochondria is particularly vital for neurons because of their polarized structure and high energy demand. Mitochondria in axons constantly move in response to physiological needs, but signals that regulate mitochondrial movement are not well understood. Aside from producing ATP, Ca 2+ buffering is another main function of mitochondria. Activities of many enzymes in mitochondria are also Ca 2+-dependent, suggesting that intramitochondrial Ca 2+ concentration is important for mitochondrial functions. Here, we report that mitochondrial motility in axons is actively regulated by mitochondrial matrix Ca 2+. Ca 2+ entry through the mitochondrial Ca 2+ uniporter modulates mitochondrial transport, and mitochondrial Ca 2+ content correlates inversely with the speed of mitochondrial movement. Furthermore, the miro1 protein plays a role in Ca 2+ uptake into the mitochondria, which subsequently affects mitochondrial movement.
- ; Go to Link
Appears in Collections:
- SLS_Journal Papers
can give you direct access to the published full text of this article. (UNISTARs only)
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.