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DC Field | Value | Language |
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dc.citation.endPage | 5083 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 5074 | - |
dc.citation.title | CHEMISTRY OF MATERIALS | - |
dc.citation.volume | 34 | - |
dc.contributor.author | Kim, Hyungbin | - |
dc.contributor.author | Lee, Jinhoon | - |
dc.contributor.author | Hong, Yuri | - |
dc.contributor.author | Lim, Chanoong | - |
dc.contributor.author | Lee, Dong Woog | - |
dc.contributor.author | Oh, Dongyeop X. | - |
dc.contributor.author | Waite, J. Herbert | - |
dc.contributor.author | Hwang, Dong Soo | - |
dc.date.accessioned | 2023-12-21T14:08:51Z | - |
dc.date.available | 2023-12-21T14:08:51Z | - |
dc.date.created | 2022-05-29 | - |
dc.date.issued | 2022-06 | - |
dc.description.abstract | The load-bearing proteins in mussel holdfasts rely on condensed tris-catecholato-Fe3+ coordination complexes for their toughness and shock-absorbing properties, and this feature has been successfully translated into synthetic materials with short-term high-performance properties. However, oxidation of catecholic DOPA (3,4-dihydroxyphenylalanine) remains a critical impediment to achieving materials with longer-lasting performance. Here, following the natural mussel pathway for protein processing, we explore how DOPA oxidation impacts coacervation of mussel foot protein-1 (mfp-1) and its capacity for phase-specific metal uptake in vitro. Without metal, DOPA oxidation changed the rheological properties (i.e., viscosity, loss, and storage moduli) of mfp-1 coacervate droplets. However, oxidation-dependent changes were recovered with dithiothreitol (DTT), completely restoring the behavior of mfp-1 coacervates prior to oxidation. With metal, mfp-1 coacervates exhibited gel-like behavior with high viscosity and cohesive forces by forming recognizable bis- and tris-catecholato-Fe complexes, linked to increased energy dissipation and toughness of byssus. These results indicate that Fe3+-mediated conversion of liquid-liquid phase-separated polymers into metal-coordinated networks is thorough and rapid, and DTT effectively maintains redox integrity. Our study provides much-needed improvements for processing catechol-functionalized polymers into high-performance materials. | - |
dc.identifier.bibliographicCitation | CHEMISTRY OF MATERIALS, v.34, no.11, pp.5074 - 5083 | - |
dc.identifier.doi | 10.1021/acs.chemmater.2c00406 | - |
dc.identifier.issn | 0897-4756 | - |
dc.identifier.scopusid | 2-s2.0-85131671162 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/58586 | - |
dc.identifier.wosid | 000812034100001 | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Essential Role of Thiols in Maintaining Stable Catecholato-Iron Complexes in Condensed Materials | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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