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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 1423 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1412 | - |
dc.citation.title | FEBS LETTERS | - |
dc.citation.volume | 596 | - |
dc.contributor.author | Yasuda, Kyota | - |
dc.contributor.author | Watanabe, Tomonobu M. | - |
dc.contributor.author | Kang, Myeong-Gyun | - |
dc.contributor.author | Seo, Jeong Kon | - |
dc.contributor.author | Rhee, Hyun-Woo | - |
dc.contributor.author | Tate, Shin-ichi | - |
dc.date.accessioned | 2023-12-21T14:09:11Z | - |
dc.date.available | 2023-12-21T14:09:11Z | - |
dc.date.created | 2022-05-09 | - |
dc.date.issued | 2022-06 | - |
dc.description.abstract | Fused in sarcoma (FUS), a DNA/RNA-binding protein, undergoes liquid-liquid phase separation to form granules in cells. Aberrant FUS granulation is associated with neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal lobar degeneration. We found that FUS granules contain a multifunctional AAA ATPase, valosin-containing protein (VCP), which is known as a key regulator of protein degradation. FUS granule stability depends on ATP concentrations in cells. VCP ATPase changes the FUS granule stability time-dependently by consuming ATP to reduce its concentrations in the granules: VCPs in de novo FUS granules stabilize the granules, while long-lasting VCP colocalization destabilizes the granules. The proteolysis-promoting function of VCP may subsequently dissolve the unstabilized granules. We propose that VCP colocalized to the FUS granules acts as a timer to limit the residence time of the granules in cells. | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, v.596, no.11, pp.1412 - 1423 | - |
dc.identifier.doi | 10.1002/1873-3468.14353 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.scopusid | 2-s2.0-85128857676 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/58436 | - |
dc.identifier.url | https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14353 | - |
dc.identifier.wosid | 000786547400001 | - |
dc.language | 영어 | - |
dc.publisher | WILEY | - |
dc.title | Valosin-containing protein regulates the stability of fused in sarcoma granules in cells by changing ATP concentrations | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Biophysics; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Biophysics; Cell Biology | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | ALS | - |
dc.subject.keywordAuthor | ATP | - |
dc.subject.keywordAuthor | FUS | - |
dc.subject.keywordAuthor | liquid-liquid phase separation | - |
dc.subject.keywordAuthor | VCP | - |
dc.subject.keywordPlus | RNA-BINDING PROTEIN | - |
dc.subject.keywordPlus | VCP MUTATIONS | - |
dc.subject.keywordPlus | STRESS GRANULES | - |
dc.subject.keywordPlus | AAA-ATPASE | - |
dc.subject.keywordPlus | LOCALIZATION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | DOMAIN | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | PROTEASOME | - |
dc.subject.keywordPlus | AUTOPHAGY | - |
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