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DC Field | Value | Language |
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dc.citation.endPage | + | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1848 | - |
dc.citation.title | CELL | - |
dc.citation.volume | 183 | - |
dc.contributor.author | Ringel, Alison E. | - |
dc.contributor.author | Drijvers, Jefte M. | - |
dc.contributor.author | Baker, Gregory J. | - |
dc.contributor.author | Catozzi, Alessia | - |
dc.contributor.author | Garcia-Canaveras, Juan C. | - |
dc.contributor.author | Gassaway, Brandon M. | - |
dc.contributor.author | Miller, Brian C. | - |
dc.contributor.author | Juneja, Vikram R. | - |
dc.contributor.author | Nguyen, Thao H. | - |
dc.contributor.author | Joshi, Shakchhi | - |
dc.contributor.author | Yao, Cong-Hui | - |
dc.contributor.author | Yoon, Haejin | - |
dc.contributor.author | Sage, Peter T. | - |
dc.contributor.author | LaFleur, Martin W. | - |
dc.contributor.author | Trombley, Justin D. | - |
dc.contributor.author | Jacobson, Connor A. | - |
dc.contributor.author | Maliga, Zoltan | - |
dc.contributor.author | Gygi, Steven P. | - |
dc.contributor.author | Sorger, Peter K. | - |
dc.contributor.author | Rabinowitz, Joshua D. | - |
dc.contributor.author | Sharpe, Arlene H. | - |
dc.contributor.author | Haigis, Marcia C. | - |
dc.date.accessioned | 2023-12-21T16:37:20Z | - |
dc.date.available | 2023-12-21T16:37:20Z | - |
dc.date.created | 2022-03-08 | - |
dc.date.issued | 2020-12 | - |
dc.description.abstract | Obesity is a major cancer risk factor, but how differences in systemic metabolism change the tumor microenvironment (TME) and impact anti-tumor immunity is not understood. Here, we demonstrate that high-fat diet (HFD)-induced obesity impairs CD8(+) T cell function in the murine TME, accelerating tumor growth. We generate a single-cell resolution atlas of cellular metabolism in the TME, detailing how it changes with diet-induced obesity. We find that tumor and CD8(+) T cells display distinct metabolic adaptations to obesity. Tumor cells increase fat uptake with HFD, whereas tumor-infiltrating CD8(+) T cells do not. These differential adaptations lead to altered fatty acid partitioning in HFD tumors, impairing CD8(+) T cell infiltration and function. Blocking metabolic reprogramming by tumor cells in obese mice improves anti-tumor immunity. Analysis of human cancers reveals similar transcriptional changes in CD8(+) T cell markers, suggesting interventions that exploit metabolism to improve cancer immunotherapy. | - |
dc.identifier.bibliographicCitation | CELL, v.183, no.7, pp.1848 - + | - |
dc.identifier.doi | 10.1016/j.cell.2020.11.009 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.scopusid | 2-s2.0-85097881150 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/58157 | - |
dc.identifier.wosid | 000602900800010 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Cell Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | T-CELL METABOLISM | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | DIET | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | CHECKPOINT | - |
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