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DC Field | Value | Language |
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dc.citation.endPage | 9594 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 9579 | - |
dc.citation.title | CERAMICS INTERNATIONAL | - |
dc.citation.volume | 48 | - |
dc.contributor.author | Vellaichamy, Elangovan | - |
dc.contributor.author | Ravichandran, K. | - |
dc.contributor.author | Jariya S. A, Iynoon | - |
dc.contributor.author | Babu, Aadhil Ashwaq | - |
dc.contributor.author | Narajanan T.S.N, Sankara | - |
dc.date.accessioned | 2023-12-21T14:17:43Z | - |
dc.date.available | 2023-12-21T14:17:43Z | - |
dc.date.created | 2022-04-11 | - |
dc.date.issued | 2022-04 | - |
dc.description.abstract | In the field of orthopaedic implants, post-surgery infections and biocompatibility are the most challenging ob-stacles. Sustained and controlled antibiotic release is a key factor in novel drug delivery systems. A novel drug delivery system combined with vaterite microsphere, graphite oxide (GO), reduced graphene oxide (rGO) incorporated in a polycaprolactone (PCL) matrix on TiO2 nanotube coated Ti (TNT-Ti) is established. Anodiza-tion was employed to develop TiO2 nanotubular arrays on Ti. Ciprofloxacin hydrochloride (CPF-HCl) loaded vaterite microspheres were synthesized by in situ precipitation method. Deposition of vaterite/PCL, vaterite-GO/ PCL and vaterite-rGO/PCL composite coating on TNT-Ti was carried out by dip coating method. The composite coatings were characterized for their phase content, morphological features and functional groups. Among the three types of composite coatings, vaterite-rGO/PCL composite coating is found to be capable of encapsulating CPF-HCl to a level of 75.14 mu g. The drug release profile of CPF-HCl from the vaterite-rGO/PCL composite coating exhibits a controlled release amounting to only 35.02 % of release at the end of 120 h. The vaterite-rGO/PCL composite coating exhibits a low dissolution rate and possesses adequate bioactivity in HBSS and SBF solu-tions at 37?degrees C for 14 and 10 days, respectively. The in situ loaded CPF-HCL drug on vaterite microspheres, PCL polymer matrix and GO/rGO nanofillers does not affect the cytocompatibility and all the composite coatings supported cell viability and proliferation. The ability of vaterite-rGO/PCL composite coating to provide a slow and steady release of antibiotics with sufficient bioactivity and biocompatibility at the tissue implant interface makes it a promising for osteomyelitis infection of bone tissue implant materials. | - |
dc.identifier.bibliographicCitation | CERAMICS INTERNATIONAL, v.48, no.7, pp.9579 - 9594 | - |
dc.identifier.doi | 10.1016/j.ceramint.2021.12.156 | - |
dc.identifier.issn | 0272-8842 | - |
dc.identifier.scopusid | 2-s2.0-85121777855 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/58132 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0272884221039390?via%3Dihub | - |
dc.identifier.wosid | 000772640300001 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Development of a novel smart carrier for drug delivery: Ciprofloxacin loaded vaterite/reduced graphene oxide/PCL composite coating on TiO2 nanotube coated titanium | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Ceramics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Graphene oxide | - |
dc.subject.keywordAuthor | Reduced graphene oxide | - |
dc.subject.keywordAuthor | PCL | - |
dc.subject.keywordAuthor | Vaterite | - |
dc.subject.keywordAuthor | Sustained release | - |
dc.subject.keywordAuthor | Biocompatibility | - |
dc.subject.keywordPlus | CALCIUM-CARBONATE NANOPARTICLES | - |
dc.subject.keywordPlus | SCAFFOLDS | - |
dc.subject.keywordPlus | POLYCAPROLACTONE | - |
dc.subject.keywordPlus | HYDROXYAPATITE | - |
dc.subject.keywordPlus | MICROSPHERES | - |
dc.subject.keywordPlus | BIOACTIVITY | - |
dc.subject.keywordPlus | FUNCTIONALIZATION | - |
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