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DC Field | Value | Language |
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dc.citation.number | 16 | - |
dc.citation.title | JCI INSIGHT | - |
dc.citation.volume | 6 | - |
dc.contributor.author | Lee, SangJoon | - |
dc.contributor.author | Ishitsuka, Akari | - |
dc.contributor.author | Kuroki, Takahiro | - |
dc.contributor.author | Lin, Yu-Hsien | - |
dc.contributor.author | Shibuya, Akira | - |
dc.contributor.author | Hongu, Tsunaki | - |
dc.contributor.author | Funakoshi, Yuji | - |
dc.contributor.author | Kanaho, Yasunori | - |
dc.contributor.author | Nagata, Kyosuke | - |
dc.contributor.author | Kawaguchi, Atsushi | - |
dc.date.accessioned | 2023-12-21T15:19:52Z | - |
dc.date.available | 2023-12-21T15:19:52Z | - |
dc.date.created | 2022-03-08 | - |
dc.date.issued | 2021-08 | - |
dc.description.abstract | Asthma is a chronic inflammatory disease of the airways associated with excess production of Th2 cytokines and lung eosinophil accumulation. This inflammatory response persists in spite of steroid administration that blocks autocrine/paracrine loops of inflammatory cytokines, and the detailed mechanisms underlying asthma exacerbation remain unclear. Here, we show that asthma exacerbation is triggered by airway macrophages through a prion-like cell-to-cell transmission of extracellular particulates, including ASC protein, that assemble inflammasomes and mediate IL-1 beta production. OVA-induced allergic asthma and associated IL-1 beta production were alleviated in mice with small GTPase Arf6-deficient macrophages. The extracellular ASC specks were slightly engulfed by Arf6(-/- )macrophages, and the IL-1 beta production was reduced in Arf6(-/-) macrophages compared with that in WT macrophages. Furthermore, pharmacological inhibition of the Arf6 guanine nucleotide exchange factor suppressed asthma-like allergic inflammation in OVA-challenged WT mice. Collectively, the Arf6-dependent intercellular transmission of extracellular ASC specks contributes to the amplification of allergic inflammation and subsequent asthma exacerbation. | - |
dc.identifier.bibliographicCitation | JCI INSIGHT, v.6, no.16 | - |
dc.identifier.doi | 10.1172/jci.insight.139190 | - |
dc.identifier.issn | 2324-7703 | - |
dc.identifier.scopusid | 2-s2.0-85113381554 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/57769 | - |
dc.identifier.wosid | 000689638200001 | - |
dc.language | 영어 | - |
dc.publisher | AMER SOC CLINICAL INVESTIGATION INC | - |
dc.title | Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | NLRP3 INFLAMMASOME | - |
dc.subject.keywordPlus | GUANINE-NUCLEOTIDE | - |
dc.subject.keywordPlus | ALVEOLAR MACROPHAGES | - |
dc.subject.keywordPlus | ADAPTER ASC | - |
dc.subject.keywordPlus | BREFELDIN-A | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | LUNG | - |
dc.subject.keywordPlus | EXCHANGE | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | EXPRESSION | - |
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